-
E.
Freireich
(2006)
The investigational new drug application—who benefits?
Nature Clinical Practice Oncology, 3
-
Ronit
Ben-Romano,
A.
Rudich,
A.
Tirosh,
R.
Potashnik,
T.
Sasaoka,
K.
Riesenberg,
F.
Schlaeffer,
N.
Bashan,
N.
Bashan
(2004)
Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-ζ
Diabetologia, 47
-
E.
Mimnaugh,
Wanping
Xu,
M.
Vos,
Xitong
Yuan,
J.
Isaacs,
K.
Bisht,
D.
Gius,
L.
Neckers
(2004)
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.
Molecular cancer therapeutics, 3 5
-
Yang
Yang,
T.
Ikezoe,
T.
Takeuchi,
Y.
Adachi,
Y.
Ohtsuki,
S.
Takeuchi,
H.
Koeffler,
H.
Taguchi
(2005)
HIV‐1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling
Cancer Science, 96
-
R.
Nahta,
L.
Yuan,
Bing
Zhang,
R.
Kobayashi,
F.
Esteva
(2005)
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells.
Cancer research, 65 23
-
M.
Schütt,
J.
Zhou,
Markus
Meier,
H.
Klein
(2004)
Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells.
The Journal of endocrinology, 183 3
-
(2007)
American Association for Cancer clincancerres.aacrjournals.org Downloaded from
-
K.
O'Connor,
B.
Roth
(2005)
Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery
Nature Reviews Drug Discovery, 4
-
A.
Jemal,
R.
Siegel,
Elizabeth
Ward,
Taylor
Murray,
Jiaquan
Xu,
Carol
Smigal,
M.
Thun
(2006)
Cancer Statistics, 2006
CA: A Cancer Journal for Clinicians, 56
-
L.
Maggiorella,
B.
Wen,
V.
Frascogna,
P.
Opolon,
J.
Bourhis,
E.
Deutsch
(2005)
Combined radiation sensitizing and anti-angiogenic effects of ionizing radiation and the protease inhibitor ritonavir in a head and neck carcinoma model.
Anticancer research, 25 6B
-
S.
Lenk,
D.
Bhat,
W.
Blakeney,
W.
Dunn
(1992)
Effects of streptozotocin-induced diabetes on rough endoplasmic reticulum and lysosomes of rat liver.
The American journal of physiology, 263 5 Pt 1
-
Business
David
(2006)
Drive for drugs leads to baby clinical trials
Nature, 440
-
V.
Pai,
M.
Nahata
(1999)
Nelfinavir Mesylate: A Protease Inhibitor
, 33
-
M.
Kurowski,
B.
Kaeser,
A.
Sawyer,
M.
Popescu,
A.
Mrozikiewicz
(2002)
Low‐dose ritonavir moderately enhances nelfinavir exposure
Clinical Pharmacology & Therapeutics, 72
-
R.
Garofalo,
S.
Oreña,
K.
Rafidi,
A.
Torchia,
J.
Stock,
Audrey
Hildebrandt,
Timothy
Coskran,
S.
Black,
D.
Brees,
J.
Wicks,
J.
Mcneish,
K.
Coleman
(2003)
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta.
The Journal of clinical investigation, 112 2
-
A.
Opipari,
L.
Tan,
Anthony
Boitano,
D.
Sorenson,
Anjili
Aurora,
J.
Liu
(2004)
Resveratrol-induced Autophagocytosis in Ovarian Cancer Cells
Cancer Research, 64
-
Y.
Kabeya,
N.
Mizushima,
T.
Ueno,
A.
Yamamoto,
T.
Kirisako,
Takeshi
Noda,
E.
Kominami,
Y.
Ohsumi,
T.
Yoshimori
(2000)
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
The EMBO Journal, 19
-
(2007)
Cancer Therapy: Preclinical www.aacrjournals.org Clin Cancer Res
-
Maiko
Ogata,
S.
Hino,
A.
Saito,
Keisuke
Morikawa,
S.
Kondo,
S.
Kanemoto,
Tomohiko
Murakami,
M.
Taniguchi,
I.
Tanii,
K.
Yoshinaga,
Sadao
Shiosaka,
J.
Hammarback,
F.
Urano,
K.
Imaizumi
(2006)
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
Molecular and Cellular Biology, 26
-
R.
Parker,
O.
Flint,
R.
Mulvey,
Carolina
Elosua,
Faye
Wang,
W.
Fenderson,
Shulin
Wang,
Wen-pin
Yang,
Mustafa
Noor
(2005)
Endoplasmic Reticulum Stress Links Dyslipidemia to Inhibition of Proteasome Activity and Glucose Transport by HIV Protease Inhibitors
Molecular Pharmacology, 67
-
C.
Canman,
A.
Wolff,
C.
Chen,
A.
Fornace,
M.
Kastan
(1994)
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.
Cancer research, 54 19
-
S.
Nawrocki,
J.
Carew,
M.
Pino,
R.
Highshaw,
K.
Dunner,
Peng
Huang,
J.
Abbruzzese,
D.
McConkey
(2005)
Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
Cancer research, 65 24
-
A.
Monks,
D.
Scudiero,
P.
Skehan,
R.
Shoemaker,
K.
Paull,
D.
Vistica,
C.
Hose,
J.
Langley,
Paul
Cronise,
A.
Vaigro-Wolff,
Marcia
Gray-Goodrich,
H.
Campbell,
J.
Mayo,
M.
Boyd
(1991)
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
Journal of the National Cancer Institute, 83 11
-
Ted
Ashburn,
K.
Thor
(2004)
Drug repositioning: identifying and developing new uses for existing drugs
Nature Reviews Drug Discovery, 3
-
J.
Knowlden,
I.
Hutcheson,
D.
Barrow,
J.
Gee,
R.
Nicholson
(2005)
Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor.
Endocrinology, 146 11
-
E.
Blommaart,
J.
Luiken,
A.
Meijer
(1997)
Autophagic proteolysis: control and specificity
The Histochemical Journal, 29
-
P.
Chinnaiyan,
G.
Allen,
P.
Harari
(2006)
Radiation and new molecular agents, part II: targeting HDAC, HSP90, IGF-1R, PI3K, and Ras.
Seminars in radiation oncology, 16 1
-
T.
Hideshima,
P.
Richardson,
K.
Anderson
(2006)
Current therapeutic uses of lenalidomide in multiple myeloma
Expert Opinion on Investigational Drugs, 15
-
Anne
Monks,
D.
Scudiero,
Johnson
Gs,
K.
Paull,
Edward
Sausville
(1997)
The NCI anti-cancer drug screen: a smart screen to identify effectors of novel targets.
Anti-cancer drug design, 12 7
-
Keyong
Du,
S.
Herzig,
R.
Kulkarni,
M.
Montminy
(2003)
TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver
Science, 300
-
A.
Bailer
(1988)
Testing for the equality of area under the curves when using destructive measurement techniques
Journal of Pharmacokinetics and Biopharmaceutics, 16
-
B.
Raught,
A.
Gingras,
N.
Sonenberg
(2001)
The target of rapamycin (TOR) proteins
Proceedings of the National Academy of Sciences of the United States of America, 98
-
J.
Mervis
(2005)
Productivity Counts--But the Definition Is Key
Science, 309
-
Y.
Matsui,
H.
Takagi,
X.
Qu,
M.
Abdellatif,
H.
Sakoda,
T.
Asano,
B.
Levine,
J.
Sadoshima
(2007)
Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy
Circulation Research, 100
-
Tomohiro
Yorimitsu,
Usha
Nair,
Zhifen
Yang,
D.
Klionsky
(2006)
Endoplasmic Reticulum Stress Triggers Autophagy*
Journal of Biological Chemistry, 281
-
Wei
Jiang,
P.
Mikochik,
Jin
Ra,
H.
Lei,
K.
Flaherty,
J.
Winkler,
F.
Spitz
(2007)
HIV protease inhibitor nelfinavir inhibits growth of human melanoma cells by induction of cell cycle arrest.
Cancer research, 67 3
-
D.
Altomare,
J.
Testa
(2005)
Perturbations of the AKT signaling pathway in human cancer
Oncogene, 24
-
L.
Milas,
U.
Raju,
Z.
Liao,
J.
Ajani
(2005)
Targeting molecular determinants of tumor chemo-radioresistance.
Seminars in oncology, 32 6 Suppl 9
-
J.
Tsurutani,
J.
Fukuoka,
H.
Tsurutani,
J.
Shih,
S.
Hewitt,
W.
Travis,
J.
Jen,
P.
Dennis
(2006)
Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 2
-
T.
Ikezoe,
Tsuyako
Saito,
K.
Bandobashi,
Yang
Yang,
H.
Koeffler,
H.
Taguchi
(2004)
HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2.
Molecular cancer therapeutics, 3 4
-
P.
Seglen,
P.
Gordon
(1982)
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America, 79 6
-
A.
Mhaka,
A.
Gady,
D.
Rosen,
K.
Lo,
S.
Gillies,
S.
Denmeade
(2004)
Use of Methotrexate-Based Peptide Substrates to Characterize the Substrate Specificity of Prostate-Specific Membrane Antigen (PSMA)
Cancer Biology & Therapy, 3
-
F.
Pajonk,
Judith
Himmelsbach,
K.
Riess,
A.
Sommer,
W.
McBride
(2002)
The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells.
Cancer research, 62 18
-
W.
Bursch,
A.
Ellinger,
H.
Kienzl,
L.
Török,
S.
Pandey,
M.
Sikorska,
Roy
Walker,
R.
Hermann
(1996)
Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy.
Carcinogenesis, 17 8
-
A.
Mandic,
J.
Hansson,
S.
Linder,
M.
Shoshan
(2003)
Cisplatin Induces Endoplasmic Reticulum Stress and Nucleus-independent Apoptotic Signaling*
The Journal of Biological Chemistry, 278
-
E.
Mimnaugh,
Wanping
Xu,
M.
Vos,
Xitong
Yuan,
L.
Neckers
(2006)
Endoplasmic Reticulum Vacuolization and Valosin-Containing Protein Relocalization Result from Simultaneous Hsp90 Inhibition by Geldanamycin and Proteasome Inhibition by Velcade
Molecular Cancer Research, 4
-
C.
Sgadari,
G.
Barillari,
E.
Toschi,
D.
Carlei,
Ilaria
Bacigalupo,
S.
Baccarini,
C.
Palladino,
P.
Leone,
R.
Bugarini,
L.
Malavasi,
A.
Cafaro,
M.
Falchi,
D.
Valdembri,
G.
Rezza,
F.
Bussolino,
P.
Monini,
B.
Ensoli
(2002)
HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma
Nature Medicine, 8
-
P.
Tebas,
W.
Powderly
(2000)
Nelfinavir mesylate
Expert Opinion on Pharmacotherapy, 1
-
Anjali
Gupta,
G.
Cerniglia,
R.
Mick,
W.
McKenna,
R.
Muschel
(2005)
HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo.
Cancer research, 65 18
-
P.
Monini,
C.
Sgadari,
E.
Toschi,
G.
Barillari,
B.
Ensoli
(2004)
Antitumour effects of antiretroviral therapy
Nature Reviews Cancer, 4
-
M.
Markowitz,
Marcus
Conant,
A.
Hurley,
Rosemary
Schluger,
Margarita
Duran,
Joanna
Peterkin,
Sharon
Chapman,
A.
Patick,
Amy
Hendricks,
Geoffrey
Yuen,
William
Hoskins,
Neil
Clendeninn,
David
Ho
(1998)
A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV)-1 protease, to treat HIV infection.
The Journal of infectious diseases, 177 6
