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References (25)
-
D. Zipris, E. Lien, Jenny Xie, D. Greiner, J. Mordes, A. Rossini (2005)
TLR Activation Synergizes with Kilham Rat Virus Infection to Induce Diabetes in BBDR Rats1The Journal of Immunology, 174
-
H. Anders, B. Banas, D. Schlöndorff (2004)
Signaling danger: toll-like receptors and their potential roles in kidney disease.Journal of the American Society of Nephrology : JASN, 15 4
-
A. Shirali, D. Goldstein (2008)
Tracking the toll of kidney disease.Journal of the American Society of Nephrology : JASN, 19 8
-
Kyung Ahn, S. Lim, Can Li, H. Yang, J. Ghee, J. Kim, S. Kim, J. Kim, Chul-woo Yang (2007)
Influence of Angiotensin II on Expression of Toll-like Receptor 2 and Maturation of Dendritic Cells in Chronic Cyclosporine NephropathyTransplantation, 83
-
D. Conrad (2005)
Faculty Opinions recommendation of Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. -
G. King (2008)
The role of inflammatory cytokines in diabetes and its complications.Journal of periodontology, 79 8 Suppl
-
R. Vabulas, P. Ahmad-Nejad, S. Ghose, C. Kirschning, R. Issels, H. Wagner (2002)
HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway*The Journal of Biological Chemistry, 277
-
B. Tesar, D. Goldstein (2007)
Toll-like receptors and their role in transplantation.Frontiers in bioscience : a journal and virtual library, 12
-
M. Dasu, S. Devaraj, Samuel Park, I. Jialal (2010)
Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic SubjectsDiabetes Care, 33
-
N. Yang, Ming-qian Luo, Ronglin Li, Yuefang Huang, Rui Zhang, Qingqing Wu, Fang Wang, Youji Li, Xueqing Yu (2007)
Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 23 1
-
G. Johnson, G. Brunn, J. Platt (2003)
Activation of mammalian Toll-like receptors by endogenous agonists.Critical reviews in immunology, 23 1-2
-
坪井 直毅 (2004)
Roles of Toll-like receptors in C-C chemokine production by renal tubular epithelial cells -
B. Kim, S. Lim, Can Li, Jung Kim, B. Sun, Kyung Ahn, S. Han, J. Kim, Chul-woo Yang (2005)
Ischemia-Reperfusion Injury Activates Innate Immunity in Rat KidneysTransplantation, 79
-
(2008)
Jialal I: High glucose induces Toll-like receptor expression in human monocytes: mechanism of activation -
R. Medzhitov, CharleS. Janeway (2000)
Innate immune recognition: mechanisms and pathwaysImmunological Reviews, 173
-
E. Ritz, I. Rychlík, F. Locatelli, S. Halimi (1999)
End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions.American journal of kidney diseases : the official journal of the National Kidney Foundation, 34 5
-
S. Akira, K. Takeda, T. Kaisho (2001)
Toll-like receptors: critical proteins linking innate and acquired immunityNature Immunology, 2
-
Ping Zhang, M. Lun, C. Schworer, T. Blasick, K. Masker, Jay Jones, D. Carey (2008)
Heat shock protein expression is highly sensitive to ischemia-reperfusion injury in rat kidneys.Annals of clinical and laboratory science, 38 1
-
M. Robson (2009)
Toll-Like Receptors and Renal DiseaseNephron Experimental Nephrology, 113
-
J. Leemans, G. Stokman, N. Claessen, Kasper Rouschop, Gwendoline Teske, C. Kirschning, S. Akira, T. Poll, J. Weening, S. Florquin (2005)
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.The Journal of clinical investigation, 115 10
-
Prashant Patole, Rahul Pawar, M. Lech, D. Zecher, Holger Schmidt, S. Segerer, Andreas Ellwart, A. Henger, M. Kretzler, H. Anders (2006)
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 21 11
-
T. Wolfs, W. Buurman, A. Schadewijk, B. Vries, M. Daemen, P. Hiemstra, C. Veer (2002)
In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation1The Journal of Immunology, 168
-
O. Adachi, T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, S. Akira (1998)
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.Immunity, 9 1
-
S. Frantz, R. Kelly, T. Bourcier (2001)
Role of TLR-2 in the Activation of Nuclear Factor κB by Oxidative Stress in Cardiac Myocytes*The Journal of Biological Chemistry, 276
-
H. Brown, S. Sacks, M. Robson (2006)
Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis.Journal of the American Society of Nephrology : JASN, 17 7
- Publisher
- Karger
- Copyright
- © 2010 S. Karger AG, Basel
- ISSN
- 0250-8095
- eISSN
- 1421-9670
- DOI
- 10.1159/000317023
- Publisher site
- See Article on Publisher Site
Abstract
Background/Aims: Inflammation is implicated in the pathogenesis of diabetic nephropathy (DN). This study examined the role of Toll-like receptor 2 (TLR2) in the progression of renal injury in a model of rat DN. Methods: DN was induced by intravenous injection of streptozotocin and rats were sacrificed at week 2, 4 and 8. Functional and pathologic markers, inflammatory infiltration, expression of TLR2, MCP-1, MyD88, HSP70, HMGB1 and activation of NF-ĸB were assessed. The effects of glucose on the expression of TLR2 by renal tubular epithelial cells were also examined in vitro. Results: The expression of TLR2 mRNA and protein level was significantly upregulated in the kidneys of diabetic rats (p < 0.01), which was associated with increased renal expression of MyD88 and MCP-1, activation of NF-ĸB and infiltration of macrophages. The expression of HSP70 and HMGB1, endogenous ligands of TLRs, was also significantly upregulated in the kidneys of diabetic rats. In human renal biopsy of DN, there was prominent expression of TLR2 in both the glomeruli and tubulointerstitium. In vitro study showed that high glucose induced the expression of TLR2 mRNA by NRK-52E cells (p < 0.01). Conclusions: Enhanced renal expression of TLR2 is associated with inflammatory infiltration in DN.
Journal
American Journal of Nephrology – Karger
Published: Jan 1, 2010
Keywords: Inflammation; Diabetic nephropathy; Toll-like receptor 2