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(2010)
Reproduced with the permission -
(2005)
Pseu-do-continuous Flow Driven Adiabatic Inversion for Arterial Spin Labeling -
L. Lüdemann, C. Warmuth, M. Plotkin, A. Förschler, M. Gutberlet, P. Wust, H. Amthauer (2009)
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- Publisher
- Karger
- Copyright
- © 2010 S. Karger AG, Basel
- ISSN
- 0014-3022
- eISSN
- 1421-9913
- DOI
- 10.1159/000311520
- Publisher site
- See Article on Publisher Site
Abstract
Purpose: To prove the feasibility of arterial spin labeling (ASL) to explore brain tumors by comparing dynamic susceptibility contrast-enhanced MRI to ASL at 3T MR. Materials and Methods: Twenty-seven patients were included presenting 9 gliomas, 10 metastases and 8 meningiomas. All were explored by a pseudo-continuous ASL and dynamic susceptibility contrast-enhanced T2* perfusion sequence. Two neuroradiologists analyzed the cerebral blood flow (CBF) maps to assess feasibility, examination quality and quantitative comparison. The Spearman nonparametric correlation test and the Bland-Altman graphic test were used to analyze our quantitative results. Results: 92% of ASL CBF maps were informative. ASL detected all lesions as well as dynamic susceptibility contrast-enhanced MRI. Both sequences provide relative quantitative CBF values closely correlated. Conclusion: On a 3T MR unit, ASL is a good alternative to dynamic susceptibility contrast-enhanced MRI when contrast medium is contraindicated or intravenous injection is not possible. Its results on relative CBF parameters are similar to contrast-injected perfusion.
Journal
European Neurology – Karger
Published: Jan 1, 2010
Keywords: Arterial spin labeling; Perfusion; Cerebral blood flow; Cerebral neoplasm; 3T MR