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References (37)
-
S. Sariban-Sohraby, M. Abramow, R. Fisher (1992)
Single-channel behavior of a purified epithelial Na+ channel subunit that binds amiloride.The American journal of physiology, 263 5 Pt 1
-
BC Rossier (1992)
1373 -
D. Seldin, G. Giebisch (1992)
The Kidney: Physiology and Pathophysiology -
N. Unwin (1993)
Neurotransmitter action: Opening of ligand-gated ion channelsCell, 72
-
M. Driscoll, M. Chalfie (1992)
Developmental and abnormal cell death in C. ElegansTrends in Neurosciences, 15
-
F. Guharay, F. Sachs (1984)
Stretch‐activated single ion channel currents in tissue‐cultured embryonic chick skeletal muscle.The Journal of Physiology, 352
-
C. Canessa, J. Horisberger, B. Rossier (1993)
Epithelial sodium channel related to proteins involved in neurodegenerationNature, 361
-
A. Kemendy, T. Kleyman, D. Eaton (1992)
Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia.The American journal of physiology, 263 4 Pt 1
-
D. Ausiello, J. Stow, H. Cantiello, J. Almeida, D. Benos (1992)
Purified epithelial Na+ channel complex contains the pertussis toxin-sensitive G alpha i-3 protein.The Journal of biological chemistry, 267 7
-
V. Taglietti, M. Toselli (1988)
A study of stretch‐activated channels in the membrane of frog oocytes: interactions with Ca2+ ions.The Journal of Physiology, 407
-
P. Vigne, G. Champigny, R. Marsault, P. Barbry, C. Frelin, M. Lazdunski (1989)
A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels.The Journal of biological chemistry, 264 13
-
F. Jørgensen, H. Ohmori (1988)
Amiloride blocks the mechano‐electrical transduction channel of hair cells of the chick.The Journal of Physiology, 403
-
D. Goldberg, M. Frischer, S. Green (1993)
Sex surveys and drug usersNature, 361
-
C. Bear (1990)
A nonselective cation channel in rat liver cells is activated by membrane stretch.The American journal of physiology, 258 3 Pt 1
-
C Van Renterghem (1991)
401Pflügers Arch., 419
-
H. Ohmori (1984)
Studies of ionic currents in the isolated vestibular hair cell of the chick.The Journal of Physiology, 350
-
(1988)
SODIUM CHANNEL SUB UNIT STRUCTURE I CHEMTRACTS-BIOCHEMISTRY AND MOLECULAR BIOLOGY -
Mingxia Huang, M. Chalfie (1994)
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegansNature, 367
-
A. Hudspeth (1986)
The ionic channels of a vertebrate hair cellHearing Research, 22
-
L. Palmer (1992)
Epithelial Na channels: function and diversity.Annual review of physiology, 54
-
E. Lingueglia, N. Voilley, R. Waldmann, M. Lazdunski, P. Barbry (1993)
Expression cloning of an epithelial amiloride‐sensitive Na+ channelFEBS Letters, 318
-
Pascal Barbry, M. Champe, Olivier Chassande, S. Munemitsu, G. Champigny, E. Lingueglia, P. Maes, Christian Frelin, A. Tartar, Axel Ullrich (1990)
Human kidney amiloride-binding protein: cDNA structure and functional expression.Proceedings of the National Academy of Sciences of the United States of America, 87
-
L. Palmer, I. Corthésy-Theulaz, H. Gaeggeler, J. Kraehenbuhl, B. Rossier (1990)
Expression of epithelial Na channels in Xenopus oocytesThe Journal of General Physiology, 96
-
W. Catterall (1992)
Cellular and molecular biology of voltage-gated sodium channels.Physiological reviews, 72 4 Suppl
-
CM Canessa (1993)
864J. Am. Soc. Nephrol., 4
-
D. Benos, G. Saccomani, S. Sariban-Sohraby (1987)
The epithelial sodium channel. Subunit number and location of the amiloride binding site.The Journal of biological chemistry, 262 22
-
M. Chalfie, M. Driscoll, Mingxia Huang (1993)
Degenerin similaritiesNature, 361
-
L. Palmer, G. Frindt (1986)
Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule.Proceedings of the National Academy of Sciences of the United States of America, 83 8
-
A. Prat, A. Bertorello, Dennis Ausiello, Horacio Cantiello (1993)
Activation of epithelial Na+ channels by protein kinase A requires actin filaments.The American journal of physiology, 265 1 Pt 1
-
K. Hong, M. Driscoll (1994)
A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegansNature, 367
-
B. Martinac, M. Buechner, A. Delcour, J. Adler, C. Kung (1987)
Pressure-sensitive ion channel in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America, 84 8
-
Michael Gustin, Xin-liang Zhou, Boris Martinac, Ching Kung (1988)
A mechanosensitive ion channel in the yeast plasma membrane.Science, 242 4879
-
H. Garty, D. Benos (1988)
Characteristics and regulatory mechanisms of the amiloride-blockable Na+ channel.Physiological reviews, 68 2
-
O. Pongs (1992)
Molecular biology of voltage-dependent potassium channels.Physiological reviews, 72 4 Suppl
-
A. Cuthbert (1992)
The biochemical defect in cystic fibrosis.Journal of the Royal Society of Medicine, 85 Suppl 19
-
AW Cuthbert (1992)
2J. Roy. Soc. Med., 85
-
Olivier Staub, ois Verrey, R. Kleyman, D. Benos, B. Rossier, Jean-Pierre Kraehenbuhl (1992)
Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activityThe Journal of Cell Biology, 119
- Publisher
- Springer Journals
- Copyright
- Copyright © 1994 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/367463a0
- Publisher site
- See Article on Publisher Site
Abstract
THE amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is upregulated by vasopressin and aldosterone, hormones involved in the maintenance of sodium balance, blood volume and blood pressure1,2. We have identified the primary structure of the α-subunit of the rat epithelial sodium channel by expression cloning in Xenopus laevis oocytes3. An identical subunit has recently been reported4. Here we identify two other subunits (β and γ) by functional complementation of the α-subunit of the rat epithelial Na+ channel. The ion-selective permeability, the gating properties and the pharmacological profile of the channel formed by coexpressing the three subunits in oocytes are similar to that of the native channel.
Journal
Nature – Springer Journals
Published: Feb 3, 1994