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Angioinvasive Lymphomatoid Papulosis A New Variant Simulating Aggressive Lymphomas

Angioinvasive Lymphomatoid Papulosis A New Variant Simulating Aggressive Lymphomas ORIGINAL ARTICLE Angioinvasive Lymphomatoid Papulosis A New Variant Simulating Aggressive Lymphomas Werner Kempf, MD,*w Dmitry V. Kazakov, MD, PhD,z Leo Scha¨rer, MD,y Arno Rutten, MD,y Thomas Mentzel, MD,y Bruno E. Paredes, MD,y Gabriele Palmedo, PhD,y Renato G. Panizzon, MD,8 and Heinz Kutzner, MDy LyP types (A, B, C, and D) have been identified. Type A Abstract: Lymphomatoid papulosis (LyP) belongs to the spectrum is characterized by the presence of large pleomorphic or of primary cutaneous CD30-positive lymphoproliferative dis- anaplastic CD30 T cells scattered or in small clusters orders. Clinically, LyP is characterized by a variable number of within the background of eosinophilic and neutrophilic self-healing papulo-nodular lesions, with the typical waxing and granulocytes, histiocytes, and small lymphocytes. Type B waning course. Histologically, 4 types (A, B, C, and D) have been shows epidermotropic infiltrates of small-sized to me- delineated. Angioinvasive growth and large ulcers are rare findings dium-sized lymphoid cells, with variable extent of CD30 in LyP and simulate aggressive lymphoma. We retrospectively expression. In type C, a nodular dense infiltrate of cohe- analyzed the clinicopathologic and molecular features of an- sive sheets of pleomorphic or anaplastic CD30 cells is gioinvasive LyP in a series of 16 patients. This http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Surgical Pathology Wolters Kluwer Health

Angioinvasive Lymphomatoid Papulosis A New Variant Simulating Aggressive Lymphomas

Kutzner, Heinz
American Journal of Surgical Pathology , Volume 37 (1) – Jan 1, 2013
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References (75)

Copyright
Copyright © 2012 by Lippincott Williams & Wilkins
ISSN
0147-5185
eISSN
1532-0979
DOI
10.1097/PAS.0b013e3182648596
pmid
23026936
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Angioinvasive Lymphomatoid Papulosis A New Variant Simulating Aggressive Lymphomas Werner Kempf, MD,*w Dmitry V. Kazakov, MD, PhD,z Leo Scha¨rer, MD,y Arno Rutten, MD,y Thomas Mentzel, MD,y Bruno E. Paredes, MD,y Gabriele Palmedo, PhD,y Renato G. Panizzon, MD,8 and Heinz Kutzner, MDy LyP types (A, B, C, and D) have been identified. Type A Abstract: Lymphomatoid papulosis (LyP) belongs to the spectrum is characterized by the presence of large pleomorphic or of primary cutaneous CD30-positive lymphoproliferative dis- anaplastic CD30 T cells scattered or in small clusters orders. Clinically, LyP is characterized by a variable number of within the background of eosinophilic and neutrophilic self-healing papulo-nodular lesions, with the typical waxing and granulocytes, histiocytes, and small lymphocytes. Type B waning course. Histologically, 4 types (A, B, C, and D) have been shows epidermotropic infiltrates of small-sized to me- delineated. Angioinvasive growth and large ulcers are rare findings dium-sized lymphoid cells, with variable extent of CD30 in LyP and simulate aggressive lymphoma. We retrospectively expression. In type C, a nodular dense infiltrate of cohe- analyzed the clinicopathologic and molecular features of an- sive sheets of pleomorphic or anaplastic CD30 cells is gioinvasive LyP in a series of 16 patients. This

Journal

American Journal of Surgical Pathology – Wolters Kluwer Health

Published: Jan 1, 2013

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