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Effects of the prostaglandin E 2 analogue enprostil on the carbon tetrachloride‐induced necrosis of liver cells in mice

Effects of the prostaglandin E 2 analogue enprostil on the carbon tetrachloride‐induced necrosis... Female mice, eight weeks old, were injected with carbon tetrachloride (CCl4) (10 mg subcutaneously). Groups of mice (n = 10–30) were then injected with enprostil (E) 2, 20 or 50 μg/kg body weight (bw) intraperitoneally 15 min and two h after, or E 100 μg/kg bw two h after the CCl4 injection. The mice were killed after 24, 48 or 72 h. Plasma activity concentrations of alanine aminotransferase (ALAT) were determined in blood specimens from the iliac veins. The extent of liver cell necrosis in histological sections was recorded on a 100 mm Visual Analogue Scale (VAS) and measured using the electronic Mini Mop method. In the group given the highest single dose of E (100 μg/kg) a significant lowering of the CCl4‐induced liver cell necrosis was found after 24 h. No significant differences were found after 48 and 72 h. In the other groups injected with lower doses of E after CCl4, no significant differences were found compared to groups injected with CCl4 alone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Apmis Wiley

Effects of the prostaglandin E 2 analogue enprostil on the carbon tetrachloride‐induced necrosis of liver cells in mice

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References (21)

Publisher
Wiley
Copyright
© 1992 Acta Pathologica, Microbiologica et Immunologica Scandinavica
ISSN
0903-4641
eISSN
1600-0463
DOI
10.1111/j.1699-0463.1992.tb04026.x
Publisher site
See Article on Publisher Site

Abstract

Female mice, eight weeks old, were injected with carbon tetrachloride (CCl4) (10 mg subcutaneously). Groups of mice (n = 10–30) were then injected with enprostil (E) 2, 20 or 50 μg/kg body weight (bw) intraperitoneally 15 min and two h after, or E 100 μg/kg bw two h after the CCl4 injection. The mice were killed after 24, 48 or 72 h. Plasma activity concentrations of alanine aminotransferase (ALAT) were determined in blood specimens from the iliac veins. The extent of liver cell necrosis in histological sections was recorded on a 100 mm Visual Analogue Scale (VAS) and measured using the electronic Mini Mop method. In the group given the highest single dose of E (100 μg/kg) a significant lowering of the CCl4‐induced liver cell necrosis was found after 24 h. No significant differences were found after 48 and 72 h. In the other groups injected with lower doses of E after CCl4, no significant differences were found compared to groups injected with CCl4 alone.

Journal

Apmis – Wiley

Published: Jul 1, 1992

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