Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/nitric-oxide-directly-activates-calcium-dependent-potassium-channels-WX7vaI3klt
References (23)
-
P. Krippeit-Drews, N. Morel, T. Godfraind (1992)
Effect of Nitric Oxide on Membrane Potential and Contraction of Rat AortaJournal of Cardiovascular Pharmacology, 20
-
L. Toro, E. Stefani (1991)
Calcium-activated K+ channels: Metabolic regulationJournal of Bioenergetics and Biomembranes, 23
-
Tadeusz Malinski, Z. Taha, S. Grunfeld, S. Patton, M. Kapturczak, P. Tomboulian (1993)
Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors.Biochemical and biophysical research communications, 193 3
-
R. Palmer, A. Ferrige, S. Moncada (1987)
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorNature, 327
-
T. Griffith, D. Edwards, M. Lewis, A. Newby, A. Henderson (1984)
The nature of endothelium-derived vascular relaxant factorNature, 308
-
Christopher Miller, E. Moczydlowski, R. Latorre, M. Phillips (1985)
Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscleNature, 313
-
T. Lincoln, T. Cornwell (1993)
Intracellular cyclic GMP receptor proteinsThe FASEB Journal, 7
-
C. Cowan, James Palacino, S. Najibi, Richard Cohen (1993)
Potassium channel-mediated relaxation to acetylcholine in rabbit arteries.The Journal of pharmacology and experimental therapeutics, 266 3
-
J. Barrett, K. Magleby, B. Pallotta (1982)
Properties of single calcium‐activated potassium channels in cultured rat muscleThe Journal of Physiology, 331
-
Richard Knowles, S. Moncada (1992)
Nitric oxide as a signal in blood vessels.Trends in biochemical sciences, 17 10
-
J. Stamler, D. Singel, J. Loscalzo (1992)
Biochemistry of nitric oxide and its redox-activated forms.Science, 258 5090
-
S. Lipton, Yun-Beom Choi, Z. Pan, S. Lei, Huei‐Sheng Chen, N. Sucher, J. Loscalzo, D. Singel, J. Stamler (1993)
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compoundsNature, 364
-
J. Brayden, M. Nelson (1992)
Regulation of arterial tone by activation of calcium-dependent potassium channels.Science, 256 5056
-
Richard White, A. Lee, A. Shcherbatko, T. Lincoln, A. Schonbrunn, D. Armstrong (1993)
Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylationNature, 361
-
S. Lei, Z. Pan, S. Aggarwal, Huei‐Sheng Chen, Jonathan Hartman, N. Sucher, S. Lipton (1992)
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complexNeuron, 8
-
S. Moncada, M. Radomski, R. Palmer (1988)
Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function.Biochemical pharmacology, 37 13
-
C. Benham, T. Bolton, R. Lang, T. Takewaki (1986)
Calcium‐activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea‐pig mesenteric artery.The Journal of Physiology, 371
-
M. Wolin, P. Cherry, J. Rodenburg, E. Messina, Gabor Kaley (1990)
Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion.The Journal of pharmacology and experimental therapeutics, 254 3
-
J. Stamler, D. Simon, J. Osborne, M. Mullins, O. Jaraki, T. Michel, D. Singel, J. Loscalzo (1992)
S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.Proceedings of the National Academy of Sciences of the United States of America, 89 1
-
Ziad Taha, Frederick Kiechle, Tadeusz Malinski (1992)
Oxidation of nitric oxide by oxygen in biological systems monitored by porphyrinic sensor.Biochemical and biophysical research communications, 188 2
-
S. Najibi, C. Cowan, J. Palacino, Richard Cohen (1994)
Enhanced role of potassium channels in relaxations to acetylcholine in hypercholesterolemic rabbit carotid artery.The American journal of physiology, 266 5 Pt 2
-
B. Robertson, R. Schubert, Jorgen Hescheler, M. Nelson (1993)
cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells.The American journal of physiology, 265 1 Pt 1
-
M. Tare, H. Parkington, H. Coleman, T. Neild, Gregory Dusting, Gregory Dusting (1990)
Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endotheliumNature, 346
- Publisher
- Springer Journals
- Copyright
- Copyright © 1994 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/368850a0
- Publisher site
- See Article on Publisher Site
Abstract
NITRIC oxide is the major endothelium-derived relaxing factor (EDRF)1–3, and it is thought to relax smooth muscle cells by stimulation of guanylate cyclase, accumulation of its product cyclic GMP, and cGMP-dependent modification of several intracellular processes4,5, including activation of potassium channels through cGMP-dependent protein kinase6,7. Here we present evidence that both exogenous nitric oxide and native EDRF can directly activate single Ca2+-dependent K+ channels (K+ Ca) in cell-free membrane patches without requiring cGMP. Under conditions when guanylate cyclase was inhibited by methylene blue, considerable relaxation of rabbit aorta to nitric oxide persisted which was blocked by charybdotoxin, a specific inhibitor of K+ Ca channels. These studies demonstrate a novel direct action of nitric oxide on K+ Ca channels.
Journal
Nature – Springer Journals
Published: Apr 28, 1994