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Liver Ultrastructure in Methotrexate Treatment of Psoriasis

Liver Ultrastructure in Methotrexate Treatment of Psoriasis Abstract To the Editor.— Methotrexate, a folic acid antagonist, is widely used in the treatment of psoriasis, since it is capable of controlling widespread lesions refractory to other therapeutic measures. In the course of medication, various side-effects, including hepatotoxicity, have been reported; it was claimed that chronic use of the drug may lead to fibrosis and cirrhosis of the liver.1,2In the present study, livers of nine patients with psoriasis that were treated with methotrexate have been investigated by light and electron microscopy. To our knowledge, similar ultrastructural studies have not been reported so far. Four patients were men and five were women. Their ages ranged from 26 to 74 years. The dose of methotrexate used, the duration of treatment, the time of liver biopsy, and the extent of skin lesions varied from patient to patient.With the consent of the patients, percutaneous liver biopsies were performed with the use References 1. Weinstein GD, et al: Evaluation of possible chronic hepatotoxicity from methotrexate for psoriasis . Arch Dermatol 102:613-618, 1970.Crossref 2. Dahl MGC, Gregory MM, Scheurer PJ: Liver damage due to methotrexate in patients with psoriasis . Br Med J 1:625-630, 1971.Crossref 3. Ito T, Shibasaki S: Electron microscopic study on the hepatic sinusoidal wall and the fatstoring cells in the normal human liver . Arch Histol Jap 29:137-192, 1968.Crossref 4. Bronfenmajer S, Schaffner F, Popper H: Fat-storing cells (lipocytes) in human liver . Arch Pathol 82:447-453, 1966. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Liver Ultrastructure in Methotrexate Treatment of Psoriasis

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1973.01620240073033
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Methotrexate, a folic acid antagonist, is widely used in the treatment of psoriasis, since it is capable of controlling widespread lesions refractory to other therapeutic measures. In the course of medication, various side-effects, including hepatotoxicity, have been reported; it was claimed that chronic use of the drug may lead to fibrosis and cirrhosis of the liver.1,2In the present study, livers of nine patients with psoriasis that were treated with methotrexate have been investigated by light and electron microscopy. To our knowledge, similar ultrastructural studies have not been reported so far. Four patients were men and five were women. Their ages ranged from 26 to 74 years. The dose of methotrexate used, the duration of treatment, the time of liver biopsy, and the extent of skin lesions varied from patient to patient.With the consent of the patients, percutaneous liver biopsies were performed with the use References 1. Weinstein GD, et al: Evaluation of possible chronic hepatotoxicity from methotrexate for psoriasis . Arch Dermatol 102:613-618, 1970.Crossref 2. Dahl MGC, Gregory MM, Scheurer PJ: Liver damage due to methotrexate in patients with psoriasis . Br Med J 1:625-630, 1971.Crossref 3. Ito T, Shibasaki S: Electron microscopic study on the hepatic sinusoidal wall and the fatstoring cells in the normal human liver . Arch Histol Jap 29:137-192, 1968.Crossref 4. Bronfenmajer S, Schaffner F, Popper H: Fat-storing cells (lipocytes) in human liver . Arch Pathol 82:447-453, 1966.

Journal

Archives of Dermatology – American Medical Association

Published: Sep 1, 1973

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