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Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens

Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens LETTERS TO THE EDITOR, J. Pharm. Pharmac., 1973,25,1003 1003 Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens Recently we have observed that bilateral injection of ergometrine into the nucleus accumbens of rats results in a strong and long-lasting enhancement of locomotor activity (Pijnenburg, Woodruff & van Rossum, 1973). This effect was antagonized by low doses of haloperidol and pimozide. The hypothesis was proposed that this enhanced locomotor activity was elicited by a stimulation of dopamine receptors in the nucleus accumbens. We now report that administration of dopamine directly into the nucleus accumbens of nialamide-pretreated rats produces a pattern of enhanced locomotor activity similar to that seen after ergometrine. Seven male Wistar rats (200-220 g) were implanted with double barrelled cannulas in each side of the nucleus accumbens (coordinates A 9.4, L 1.2 and H -0.6 accord- ing to the atlas of Konig & Klippel, 1963). These animals were used for all experi- ments with 5-8 days between experiments. The animals were subsequently killed and brains were sectioned to determine the position of the cannulas. For details of the experimental procedure see Pijnenburg & others (1973). Injections were made by means of a 5 pl Hamilton http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmacy and Pharmacology Oxford University Press

Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens

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References (20)

Publisher
Oxford University Press
Copyright
1973 Royal Pharmaceutical Society of Great Britain
ISSN
0022-3573
eISSN
2042-7158
DOI
10.1111/j.2042-7158.1973.tb09995.x
Publisher site
See Article on Publisher Site

Abstract

LETTERS TO THE EDITOR, J. Pharm. Pharmac., 1973,25,1003 1003 Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens Recently we have observed that bilateral injection of ergometrine into the nucleus accumbens of rats results in a strong and long-lasting enhancement of locomotor activity (Pijnenburg, Woodruff & van Rossum, 1973). This effect was antagonized by low doses of haloperidol and pimozide. The hypothesis was proposed that this enhanced locomotor activity was elicited by a stimulation of dopamine receptors in the nucleus accumbens. We now report that administration of dopamine directly into the nucleus accumbens of nialamide-pretreated rats produces a pattern of enhanced locomotor activity similar to that seen after ergometrine. Seven male Wistar rats (200-220 g) were implanted with double barrelled cannulas in each side of the nucleus accumbens (coordinates A 9.4, L 1.2 and H -0.6 accord- ing to the atlas of Konig & Klippel, 1963). These animals were used for all experi- ments with 5-8 days between experiments. The animals were subsequently killed and brains were sectioned to determine the position of the cannulas. For details of the experimental procedure see Pijnenburg & others (1973). Injections were made by means of a 5 pl Hamilton

Journal

Journal of Pharmacy and Pharmacology – Oxford University Press

Published: Dec 1, 1973

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