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Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives.

Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted... Vol. 49 No. 1/2002 185–195 QUARTERLY Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives 1  2 2 1 Zygmunt Kazimierczuk , Jacqueline A. Upcroft , Peter Upcroft , Agata Górska , 3 3 Bohdan Staroœciak and Agnieszka Laudy 1 2 Institute of Chemistry, Agricultural University, Warszawa, Poland; The Queensland Institute of Medical Research, Brisbane, Australia; Medical University, Department of Pharmaceutical Microbiology, Warszawa, Poland Received: 10 September, 2001; revised: 21 January, 2002; aceppted: 2 February, 2002 Key words: benzimidazoles, antiprotozoal activity, antibacterial activity Two series of benzimidazole derivatives were sythesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-sub- stituted modified benzimidazoles. Antibacterial and antiprotozoal activity of the newly obtained compounds was studied. Some thioalkyl derivatives showed remark- able activity against nosocomial strains of Stenotrophomonas malthophilia, and an ac- tivity comparable to that of metronidazole against Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole showed the most distinct antiprotozoal activity. Benzimidazole derivatives are of wide inter- dazole-1--D-ribofuranoside (DRB) and its est because of their diverse biological activity 2-substituted derivatives show activity and clinical applications [1]. This ring system against human cytomegalovirus [6]. It is also is present in numerous antiparasitic, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Biochimica Polonica Unpaywall

Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives.

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Publisher
Unpaywall
ISSN
0001-527X
DOI
10.18388/abp.2002_3835
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Abstract

Vol. 49 No. 1/2002 185–195 QUARTERLY Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives 1  2 2 1 Zygmunt Kazimierczuk , Jacqueline A. Upcroft , Peter Upcroft , Agata Górska , 3 3 Bohdan Staroœciak and Agnieszka Laudy 1 2 Institute of Chemistry, Agricultural University, Warszawa, Poland; The Queensland Institute of Medical Research, Brisbane, Australia; Medical University, Department of Pharmaceutical Microbiology, Warszawa, Poland Received: 10 September, 2001; revised: 21 January, 2002; aceppted: 2 February, 2002 Key words: benzimidazoles, antiprotozoal activity, antibacterial activity Two series of benzimidazole derivatives were sythesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-sub- stituted modified benzimidazoles. Antibacterial and antiprotozoal activity of the newly obtained compounds was studied. Some thioalkyl derivatives showed remark- able activity against nosocomial strains of Stenotrophomonas malthophilia, and an ac- tivity comparable to that of metronidazole against Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole showed the most distinct antiprotozoal activity. Benzimidazole derivatives are of wide inter- dazole-1--D-ribofuranoside (DRB) and its est because of their diverse biological activity 2-substituted derivatives show activity and clinical applications [1]. This ring system against human cytomegalovirus [6]. It is also is present in numerous antiparasitic,

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Acta Biochimica Polonica – Unpaywall

Published: Mar 31, 2002

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