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Prostaglandin F2α‐induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle

Prostaglandin F2α‐induced luteolysis involves activation of Signal transducer and activator of... AbbreviationAKTProtein kinase BBAXBCL2‐associated X proteinBCL2B‐cell lymphoma 2ILInterleukinPGFProstaglandinF2αPIAS3Protein inhibitor of activated STAT3STAT3Signal transducer and activator of transcription 3SOCS3Suppressor of cytokine signaling 3TNFTumor necrosis factorINTRODUCTIONThe corpus luteum is a transient gland, with a lifespan of approximately 18 days in cattle in the absence of maternal recognition of pregnancy. At the end of the luteal phase, endometrium‐derived prostaglandin F2α (PGF) induces corpus luteum regression (luteolysis); indeed, PGF induces the precipitous loss of steroidogenic capabilities and apoptosis in luteal cells (Inskeep, ; Niswender, Juengel, Silva, Rollyson, & McIntush, ; Taniguchi, Komiyama, Viger, & Okuda, ). The acute decrease in progesterone synthesis is defined as functional luteolysis, and precedes cell death and structural regression, which is known as morphological luteolysis (reviewed by Davis & Rueda, ).In cattle, PGF actions seem to be mediated, at least in part, through the activation of Early growth response 1 (EGR1) and Transforming growth factor beta 1 (TGFB1) (Hou et al., ). Prostaglandin also acutely increases Extracellular signal‐regulated kinase 1/2 (ERK1/2) and Mammalian target of rapamycin (mTOR)/p70 Ribosomal protein S6 kinase (p70S6K1) signaling, but decreases Protein kinase B/AKT phosphorylation in the corpus luteum within 15–30 min after treatment (Arvisais et al., ). The involvement of these and other signaling pathways http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Reproduction & Development Wiley

Prostaglandin F2α‐induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle

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References (47)

Publisher
Wiley
Copyright
© 2017 Wiley Periodicals, Inc.
ISSN
1040-452X
eISSN
1098-2795
DOI
10.1002/mrd.22798
pmid
28337827
Publisher site
See Article on Publisher Site

Abstract

AbbreviationAKTProtein kinase BBAXBCL2‐associated X proteinBCL2B‐cell lymphoma 2ILInterleukinPGFProstaglandinF2αPIAS3Protein inhibitor of activated STAT3STAT3Signal transducer and activator of transcription 3SOCS3Suppressor of cytokine signaling 3TNFTumor necrosis factorINTRODUCTIONThe corpus luteum is a transient gland, with a lifespan of approximately 18 days in cattle in the absence of maternal recognition of pregnancy. At the end of the luteal phase, endometrium‐derived prostaglandin F2α (PGF) induces corpus luteum regression (luteolysis); indeed, PGF induces the precipitous loss of steroidogenic capabilities and apoptosis in luteal cells (Inskeep, ; Niswender, Juengel, Silva, Rollyson, & McIntush, ; Taniguchi, Komiyama, Viger, & Okuda, ). The acute decrease in progesterone synthesis is defined as functional luteolysis, and precedes cell death and structural regression, which is known as morphological luteolysis (reviewed by Davis & Rueda, ).In cattle, PGF actions seem to be mediated, at least in part, through the activation of Early growth response 1 (EGR1) and Transforming growth factor beta 1 (TGFB1) (Hou et al., ). Prostaglandin also acutely increases Extracellular signal‐regulated kinase 1/2 (ERK1/2) and Mammalian target of rapamycin (mTOR)/p70 Ribosomal protein S6 kinase (p70S6K1) signaling, but decreases Protein kinase B/AKT phosphorylation in the corpus luteum within 15–30 min after treatment (Arvisais et al., ). The involvement of these and other signaling pathways

Journal

Molecular Reproduction & Development – Wiley

Published: Jun 1, 2017

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