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A TNFRS11B mutation is associated with BMD and risk of hip fracture

A TNFRS11B mutation is associated with BMD and risk of hip fracture r e s e a r c h h i g h l i g h t s www.nature.com/clinicalpractice/endmet resistance, but the prevalence of low testos- A TNFRS11B mutation terone levels in men with type 1 diabetes is is associated with BMD and risk unknown. Grossmann and colleagues, therefore, of hip fracture conducted a cross-sectional study to determine Evidence suggests a strong genetic influence the prevalence of testosterone deficiency and on osteoporotic fracture risk, although the basis examine the relationship between testosterone of the link with fracture, especially hip frac- levels and insulin resistance in 574 men with ture, is ill-defined. Several studies indicate an type 2 diabetes and 69 with type 1 diabetes. association between a Lys3Asn polymorphism Fasting blood samples were collected in the of osteoprotegerin (encoded by TNFRS11B) morning for determination of total testosterone and osteoporosis outcome, but the findings (TT) levels, indices of insulin resistance and are inconsistent. Nevertheless, such an asso- calculated free testosterone (cFT; adjusted ciation is feasible since osteoprotegerin inhibits for sex-hormone-binding globulin). TT and bone resorption. Moffett et al. conducted a pro- cFT levels of a randomly selected subgroup spective study in elderly women to investigate of 262 men with type http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Endocrinology Springer Journals

A TNFRS11B mutation is associated with BMD and risk of hip fracture

Nature Reviews Endocrinology , Volume 4 (7) – Jul 1, 2008
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A TNFRS11B mutation is associated with BMD and risk of hip fracture

Abstract

r e s e a r c h h i g h l i g h t s www.nature.com/clinicalpractice/endmet resistance, but the prevalence of low testos- A TNFRS11B mutation terone levels in men with type 1 diabetes is is associated with BMD and risk unknown. Grossmann and colleagues, therefore, of hip fracture conducted a cross-sectional study to determine Evidence suggests a strong genetic influence the prevalence of testosterone deficiency and on osteoporotic fracture risk, although the basis examine the relationship...
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Publisher
Springer Journals
Copyright
Copyright © 2008 by Nature Publishing Group
Subject
Medicine & Public Health; Medicine/Public Health, general; Endocrinology
ISSN
1759-5029
eISSN
1745-8374
DOI
10.1038/ncpendmet0847
Publisher site
See Article on Publisher Site

Abstract

r e s e a r c h h i g h l i g h t s www.nature.com/clinicalpractice/endmet resistance, but the prevalence of low testos- A TNFRS11B mutation terone levels in men with type 1 diabetes is is associated with BMD and risk unknown. Grossmann and colleagues, therefore, of hip fracture conducted a cross-sectional study to determine Evidence suggests a strong genetic influence the prevalence of testosterone deficiency and on osteoporotic fracture risk, although the basis examine the relationship between testosterone of the link with fracture, especially hip frac- levels and insulin resistance in 574 men with ture, is ill-defined. Several studies indicate an type 2 diabetes and 69 with type 1 diabetes. association between a Lys3Asn polymorphism Fasting blood samples were collected in the of osteoprotegerin (encoded by TNFRS11B) morning for determination of total testosterone and osteoporosis outcome, but the findings (TT) levels, indices of insulin resistance and are inconsistent. Nevertheless, such an asso- calculated free testosterone (cFT; adjusted ciation is feasible since osteoprotegerin inhibits for sex-hormone-binding globulin). TT and bone resorption. Moffett et al. conducted a pro- cFT levels of a randomly selected subgroup spective study in elderly women to investigate of 262 men with type

Journal

Nature Reviews Endocrinology – Springer Journals

Published: Jul 1, 2008

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