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- Publisher
- Springer Journals
- Copyright
- Copyright © 2002 by Adis International Limited
- Subject
- Medicine & Public Health; Pediatrics; Pharmacotherapy; Internal Medicine
- ISSN
- 1174-5878
- eISSN
- 1179-2019
- DOI
- 10.2165/00128072-200204040-00001
- pmid
- 11960510
- Publisher site
- See Article on Publisher Site
Abstract
The emerging public health problem of type 2 diabetes in youth reflects increasing rates of childhood obesity. As in adults, type 2 diabetes in children is part of the insulin resistance syndrome that includes hypertension, dyslipidemia and other atherosclerosis risk factors, and hyperandrogenism seen as premature adrenarche and polycystic ovary syndrome. Studies in children document risk factors for type 2 diabetes and associated cardiovascular risk factors, including obesity, family history, diabetic gestation, and underweight or overweight for gestational age. Genetically determined insulin resistance, or limited β-cell reserve, has been demonstrated in high risk individuals. This genetic background, considered advantageous in a feast and famine existence (the thrifty genotype), is rendered detrimental with abundant food and physical inactivity, a lifestyle demonstrated to be typical of families of children with type 2 diabetes.
Journal
Pediatric Drugs – Springer Journals
Published: Aug 31, 2012