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Recent Advances in Endometriosis With Emphasis on Pathogenesis, Molecular Pathology, and Neoplastic Transformation

Recent Advances in Endometriosis With Emphasis on Pathogenesis, Molecular Pathology, and... International Journal of Gynecological Pathology 23:316–320, Lippincott Williams & Wilkins, Baltimore © 2004 International Society of Gynecological Pathologists Review Article Recent Advances in Endometriosis With Emphasis on Pathogenesis, Molecular Pathology, and Neoplastic Transformation Michael Wells Summary: This article reviews recent advances in our understanding of endometriosis with special reference to its pathogenesis, recent molecular studies, and relationship to neoplasia. Pathogenetic factors include familial predisposition, immunological factors, cell adhesion factors, angiogenic factors, and hormonal factors. Recent molecular findings in endometriosis include the monoclonality of endometriotic cysts and loss of heterozygosity in the majority of cases associated with adenocarcinoma. Women with a long-standing history of endometriosis have an increased risk of ovarian cancer, most commonly endometrioid and clear cell adenocarcinomas. In these cases, there is a high frequency of atypia in the endometriosis, and the endometriosis and the associated ovarian carcinoma may show identical PTEN mutations. Key Words: Endometri- osis—Pathogenesis—Molecular pathology—Endometrioid adenocarcinoma. In 1921 John Sampson gave the first of three presen- togenesis in endometriosis. However, the two theories tations on endometriosis he was to make to the American are not necessarily mutually exclusive and the “coelomic Gynecological Society. In the first of these he graphi- metaplastic theory” has won recent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Gynecological Pathology Wolters Kluwer Health

Recent Advances in Endometriosis With Emphasis on Pathogenesis, Molecular Pathology, and Neoplastic Transformation

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References (44)

ISSN
0277-1691
eISSN
1538-7151
DOI
10.1097/01.pgp.0000139636.94352.89
Publisher site
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Abstract

International Journal of Gynecological Pathology 23:316–320, Lippincott Williams & Wilkins, Baltimore © 2004 International Society of Gynecological Pathologists Review Article Recent Advances in Endometriosis With Emphasis on Pathogenesis, Molecular Pathology, and Neoplastic Transformation Michael Wells Summary: This article reviews recent advances in our understanding of endometriosis with special reference to its pathogenesis, recent molecular studies, and relationship to neoplasia. Pathogenetic factors include familial predisposition, immunological factors, cell adhesion factors, angiogenic factors, and hormonal factors. Recent molecular findings in endometriosis include the monoclonality of endometriotic cysts and loss of heterozygosity in the majority of cases associated with adenocarcinoma. Women with a long-standing history of endometriosis have an increased risk of ovarian cancer, most commonly endometrioid and clear cell adenocarcinomas. In these cases, there is a high frequency of atypia in the endometriosis, and the endometriosis and the associated ovarian carcinoma may show identical PTEN mutations. Key Words: Endometri- osis—Pathogenesis—Molecular pathology—Endometrioid adenocarcinoma. In 1921 John Sampson gave the first of three presen- togenesis in endometriosis. However, the two theories tations on endometriosis he was to make to the American are not necessarily mutually exclusive and the “coelomic Gynecological Society. In the first of these he graphi- metaplastic theory” has won recent

Journal

International Journal of Gynecological Pathology – Wolters Kluwer Health

Published: Oct 1, 2004

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