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References (14)
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- Publisher
- Wiley
- Copyright
- 1981 British Pharmacological Society
- ISSN
- 0007-1188
- eISSN
- 1476-5381
- DOI
- 10.1111/j.1476-5381.1981.tb09097.x
- Publisher site
- See Article on Publisher Site
Abstract
The maximal contractile response to the prostaglandin endoperoxide H2 analogue U46619, prostaglandins E2, D2 and F2α and the sensitivity of the superfused aorta preparation to these drugs (except PGF2α) is greater in the male than the female rat. In contrast, gender differences were not observed in the response to noradrenaline or 5‐hydroxytryptamine. In previous studies, testosterone unlike oestrogen or progesterone, increased the response of both rabbit and rat aorta to U46619. We conclude that prostaglandin receptors in rat thoracic aorta may be hormonally regulated.
Journal
British Journal of Pharmacology – Wiley
Published: Jan 1, 1981