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References (41)
-
E. Bhunchet, Kaori Fujieda (1993)
Capillarization and venularization of hepatic sinusoids in porcine serum‐induced rat liver fibrosis: A mechanism to maintain liver blood flowHepatology, 18
-
(1979)
Hepatic microcirculation . In : Bioulac - Sage , Balaboud , eds -
F. Mall (1906)
A study of the structural unit of the liverAmerican Journal of Anatomy, 5
-
T. Matsumoto, M. Kawakami (1982)
The unit-concept of hepatic parenchyma--a re-examination based on angioarchitectural studies.Acta pathologica japonica, 32 Suppl 2
-
A. Rappaport, Z. Borowy, W. Lougheed, W. Lotto (1954)
Subdivision of hexagonal liver lobules into a structural and functional unit. Role in hepatic physiology and pathologyThe Anatomical Record, 119
-
Bhunchet Bhunchet, Eishi Eishi, Wake Wake (1996)
Contribution of immune response to the hepatic fibrosis induced by porcine serum in the ratHepatology, 23
-
L. Arey (1932)
On the presence of so‐called portal lobules in the seal's liverThe Anatomical Record, 51
-
M. Okuno, Yasutoshi Muto, Michimasa Kato, H. Moriwaki, A. Noma, O. Tagaya, Yoshio Tanabe (1991)
Changes in serum and hepatic levels of immunoreactive prolyl hydroxylase in two models of hepatic fibrosis in ratsJournal of Gastroenterology and Hepatology, 6
-
Prof. Krstić (1991)
Human Microscopic Anatomy -
E. Rubin, F. Hutterer, H. Popper (1968)
Experimental hepatic fibrosis without hepatocellular regeneration. A kinetic study.The American journal of pathology, 52 1
-
Matsumoto Matsumoto, Kawakami Kawakami (1982)
The unit‐concept of hepatic parenchyma: a re‐examination based on angioarchitectural studiesActa Pathol Jpn, 32
-
F. Kiernan (1834)
The Anatomy and Physiology of the LiverEdinburgh Medical and Surgical Journal, 42
-
Debeyre Debeyre (1912)
Circulation porte du lobule hepatiqueBibliogr Anat, 22
-
Kiernan (1833)
10.1098/rstl.1833.0031Philos Trans R Soc Lond (Biol), 123
-
N. Ishida, K. Nakata, K. Takase, M. Tanaka, S. Mita (1991)
The protective effects of SA3443, a novel cyclic disulfide, on chronic liver injuries in rats.Journal of hepatology, 13 2
-
Wunsche Wunsche, Preuss Preuss (1986)
Pfortaderkorbchen um Leberlappchen beweisen die Lappchengleiderung der LeberActa Anat, 125
-
F. Johnson (1918)
The isolation, shape, size, and number of the lobules of the pig's liverAmerican Journal of Anatomy, 23
-
L. Gershbein, H. Elias (1954)
Observations on the anatomy of the rat liverThe Anatomical Record, 120
-
E. Bhunchet, K. Wake (1992)
Role of mesenchymal cell populations in porcine serum‐induced rat liver fibrosisHepatology, 16
-
A. Wünsche, F. Preuß (1986)
Pfortaderkörbchen um Leberläppchen beweisen die Läppchengliederung der LeberCells Tissues Organs, 125
-
F. Teutsch (1989)
Regionality of glucose-6-phosphate hydrolysis in the liver lobule of the rat. Metabolic heterogeneity of 'portal' and 'septal' sinusoids.Acta histochemica. Supplementband, 37
-
H. Braus, C. Elze (1932)
Anatomie des Menschen: Ein Lehrbuch für Studierende und Ärzte Dritter Band Centrales Nervensystem -
Rubin Rubin, Hutterer Hutterer, Popper Popper (1968)
Experimental hepatic fibrosis without hepatocellular regenerationAm J Pathol, 52
-
A. Rappaport (1973)
The microcirculatory hepatic unit.Microvascular research, 6 2
-
B. Quistorff, P. Rømert, O. Bhenke (1993)
Histological evaluation of the zonation of colloidal gold uptake by the rat liver.Tissue & cell, 25 1
-
W. Ekataksin, K. Wake (1991)
Liver units in three dimensions: I. Organization of argyrophilic connective tissue skeleton in porcine liver with particular reference to the "compound hepatic lobule".The American journal of anatomy, 191 2
-
W. Lamers, Aage Hilberts, Erwin Furt, Jerry Smith, G. Jonges, C. Noorden, J. Janzen, R. Charles, A. Moorman (1989)
Hepatic enzymic zonation: A reevaluation of the concept of the liver acinusHepatology, 10
-
(1888)
Sur la constitution lobulaire du foie et les voies de la circulation sanguine intra - hepatique -
Teutcli (1984)
10.1007/BF00495406Histochemistry, 81
-
M. O'Doherty (1992)
Human Microscopic Anatomy. An Atlas for Students of Medicine and Biology.Journal of Anatomy, 181
-
Richard Frank (1931)
Handbuch der mikroskopischen anatomie des menschenAmerican Journal of Obstetrics and Gynecology, 21
-
H. Elias, H. Popper (1955)
Venous distribution in livers; comparison in man and experimental animals and application to the morphogenesis of cirrhosis.A.M.A. archives of pathology, 59 3
-
H. Teutsch (1988)
Regionality of glucose‐6‐phosphate hydrolysis in the liver lobule of the rat: Metabolic heterogeneity of “portal” and “septal” sinusoidsHepatology, 8
-
(1936)
A Textbook of HistologyThe Indian Medical Gazette, 71
-
(1925)
Uber das Gallenlappehen und uber die Fettroffen in einer Seehundleber -
A. Maximow, W. Bloom (1949)
A Textbook of HistologyAIBS Bulletin, 7
-
Rappaport Rappaport, Borowy Borowy, Lougheed Lougheed, Lotto Lotto (1954)
Subdivision of hexagonal liver lobutes into a structural and functional unitAnat Rec, 119
-
I. Aird (1962)
The liver and gall bladder.Nursing times, 58
-
(1910)
Morphologie du lobule Hepatique -
Teutcli Teutcli (1984)
Sex‐specific regionality of liver metabolism during starvation with special reference to the heterogeneity of the lobular peripheryHistochemistry, 81
-
E. Bhunchet, Y. Eishi, K. Wake (1996)
Contribution of immune response to the hepatic fibrosis induced by porcine serumHepatology, 23
- Publisher
- Wolters Kluwer Health
- Copyright
- Copyright © 1998 American Association for the Study of Liver Diseases
- ISSN
- 0270-9139
- eISSN
- 1527-3350
- DOI
- 10.1002/hep.510270223
- pmid
- 9462647
- Publisher site
- See Article on Publisher Site
Abstract
We re‐evaluated three schemes of liver organization: the classic lobule, the portal lobule, and Rappaport's liver acinus. The lobular angioarchitecture of normal rat liver and the three‐dimensional structure of pseudolubules found in rat livers with fibrosis induced by swine serum were compared with the classic lobule of the pig. Normal and fibrotic rat livers and pig livers were perfused, injected with either India ink or 0.75% OsO4 through the portal and/or hepatic vein, and immersionfixed. Whole lobes and hand‐cut thick sections were made transparent with a solution of benzyl benzoate and methyl salicylate. The angioarchitecture of normal rat liver differs from pig liver. In the former, terminal portal branches and central veins interdigitate, and in the latter, numerous terminal portal branches that arise from interlobular portal veins establish a vascular basket surrounding one central vein and forming classic lobule. The structure of liver acinus is never found in the pig liver. The terminal portal branch, together with the terminal hepatic artery and bile duct, are present inside each pseudolobule of fibrotic rat livers. Blood from the terminal portal branch flows through inlet venules into radiating sinusoids, and, at the periphery converges into newly formed septal and angular outlet venules; these venules terminate in fibrotic central veins located at each corner. Pseudolobules are not rugby ball‐like as Rappaport's liver acini are but are polyhedron in shape. The rat pseudolobules are comparable with the portal lobule; its structure and microcirculation are the reverse of the pig classic lobule. Rat pseudolobules are different from liver acini, as shown by the following: 1) their three‐dimensional shape is different; and 2) they have a reverse relationship to classic lobules while acini are defined to subdivide classic lobules. In normal and fibrotic rat livers, the liver unit is the portal lobule with a terminal portal branch as the axial branch and central veins at the periphery. The co‐existence of liver acini and classic lobules is doubtful.
Journal
Hepatology – Wolters Kluwer Health
Published: Feb 1, 1998