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- Publisher
- American Medical Association
- Copyright
- Copyright 2016 American Medical Association. All Rights Reserved.
- ISSN
- 2168-622X
- eISSN
- 2168-6238
- DOI
- 10.1001/jamapsychiatry.2016.2657
- pmid
- 27806159
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionIs higher cortical amyloid burden, a marker of preclinical Alzheimer disease, associated with greater self-reported loneliness in older adults with normal cognition? FindingsIn a cross-sectional study of 79 community-dwelling older adults, higher brain amyloid burden was associated with more frequent feelings of isolation, being left out, and lacking companionship, independent of sociodemographic factors, objective measures of social network, depressive and anxiety symptoms. MeaningLoneliness, characterized by subtle feelings of social detachment, may be associated with early brain changes in preclinical Alzheimer disease, prior to mild cognitive impairment.
Journal
JAMA Psychiatry – American Medical Association
Published: Dec 2, 2016