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References (5)
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W. Hughes, V. Bond, G. Brecher, E. Cronkite, R. Painter, H. Quastler, F. Sherman (1958)
CELLULAR PROLIFERATION IN THE MOUSE AS REVEALED BY AUTORADIOGRAPHY WITH TRITIATED THYMIDINE.Proceedings of the National Academy of Sciences of the United States of America, 44 5
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D. Sholl (1957)
The organization of the cerebral cortex -
L. Uzman (1960)
The histogenesis of the mouse cerebellum as studied by its tritiated thymidine uptakeJournal of Comparative Neurology, 114
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R. Sidman, I. Miale, N. Feder (1959)
Cell proliferation and migration in the primitive ependymal zone: an autoradiographic study of histogenesis in the nervous system.Experimental neurology, 1
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G. Smelser (1961)
The structure of the eye
- Publisher
- Springer Journals
- Copyright
- Copyright © 1961 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/192766b0
- Publisher site
- See Article on Publisher Site
Abstract
AUTORADIOGRAPHY with thymidine labelled with tritium has proved useful for the study of histogenesis in the mammalian brain1–6. Labelled thymidine injected into animals becomes incorporated almost exclusively into deoxyribonucleic acid of cells preparing to divide and remains in their nuclei as a permanent label; the radioactivity is diluted to half with each cell division7. When the autoradiographic method is applied to tissues of animals killed serially, one can determine the time and place of origin of cells, their route and rate of migration, and their ultimate fate.
Journal
Nature – Springer Journals
Published: Nov 25, 1961