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References (40)
-
Suhwan Chang, Ruihong Wang, K. Akagi, Kyung-Ae Kim, Betty Martin, L. Cavallone, Kathleen Cancer, D. Haines, M. Basik, P. Mai, Elizabeth Poggi, C. Isaacs, L. Looi, K. Mun, M. Greene, S. Byers, S. Teo, C. Deng, S. Sharan (2011)
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155Nature Medicine, 17
-
S. Kohlhaas, O. Garden, C. Scudamore, M. Turner, K. Okkenhaug, E. Vigorito (2009)
Regulatory T Cells Contributes to the Development of Cutting Edge: The Foxp3 Target miR-155 -
Jianwen Zhou, Wei Wang, Z. Gao, Xueling Peng, Xulin Chen, Wei Chen, Weiyi Xu, Haixiong Xu, Marie Lin, Songshan Jiang (2013)
MicroRNA-155 Promotes Glioma Cell Proliferation via the Regulation of MXI1PLoS ONE, 8
-
Nan Ling, Junyi Gu, Zhe Lei, Mengmeng Li, Jun Zhao, Hong-Tao Zhang, Xiangdong Li (2013)
microRNA-155 regulates cell proliferation and invasion by targeting FOXO3a in glioma.Oncology reports, 30 5
-
Zhen-dong Shi, Junxia Zhang, X. Qian, Lei Han, Kailiang Zhang, Luyue Chen, Jilong Liu, Yu Ren, Ming Yang, An-ling Zhang, P. Pu, C. Kang (2013)
AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression.Cancer research, 73 17
-
J. Gotzmann, A. Fischer, M. Zojer, M. Mikula, V. Proell, H. Huber, M. Jechlinger, T. Waerner, A. Weith, H. Beug, W. Mikulits (2006)
A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytesOncogene, 25
-
S. Alonso, L. Tracey, P. Ortiz, R. Pajares, A. Sánchez-Aguilera, M. Artiga, M. Piris, J. Rodríguez-Peralto
Epithelial-mesenchymal Transition as a Major Determinant a High-throughput Study in Melanoma Identifies Updated Version Material Supplementary Cited Articles Citing Articles E-mail Alerts a High-throughput Study in Melanoma Identifies Epithelial- Mesenchymal Transition as a Major Determinant of Meta -
Je-Hyun Yoon, K. Abdelmohsen, M. Gorospe (2013)
Posttranscriptional gene regulation by long noncoding RNA.Journal of molecular biology, 425 19
-
John Prensner, A. Chinnaiyan (2011)
The emergence of lncRNAs in cancer biology.Cancer discovery, 1 5
-
Ming Yang, J. Mattes (2008)
Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs.Pharmacology & therapeutics, 117 1
-
Ye Song, Qisheng Luo, Hao Long, Zheng Hu, Tianshi Que, Xi'an Zhang, Zhi-yong Li, G. Wang, Liu Yi, Zhen Liu, W. Fang, S. Qi (2014)
Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in gliomaMolecular Cancer, 13
-
D. Anastassiou, Viktoria Rumjantseva, Wei-Yi Cheng, Jianzhong Huang, P. Canoll, D. Yamashiro, J. Kandel (2011)
Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivoBMC Cancer, 11
-
S. Obad, C. Santos, A. Petri, M. Heidenblad, O. Broom, C. Ruse, Cexiong Fu, M. Lindow, J. Stenvang, E. Straarup, H. Hansen, T. Koch, D. Pappin, G. Hannon, S. Kauppinen (2011)
Silencing of microRNA families by seed-targeting tiny LNAsNature Genetics, 43
-
Zhiyong Yan, S. Che, Jianpeng Wang, Yingbin Jiao, Chao Wang, Qing-hai Meng (2015)
miR-155 contributes to the progression of glioma by enhancing Wnt/β-catenin pathwayTumor Biology, 36
-
M. Jechlinger, S. Grunert, Ido Tamir, E. Janda, S. Lüdemann, T. Waerner, P. Seither, A. Weith, H. Beug, N. Kraut (2003)
Expression profiling of epithelial plasticity in tumor progressionOncogene, 22
-
Yu-long Hu, S. Fong, C. Largman, W. Shen (2010)
HOXA9 regulates miR-155 in hematopoietic cellsNucleic Acids Research, 38
-
J. Heward, M. Lindsay (2014)
Long non-coding RNAs in the regulation of the immune responseTrends in Immunology, 35
-
F. Siebzehnrubl, Daniel Silver, Buğra Tugertimur, L. Deleyrolle, Dorit Siebzehnrubl, M. Sarkisian, Kelly Devers, A. Yachnis, Marius Kupper, Daniel Neal, N. Nabilsi, M. Kladde, O. Suslov, S. Brabletz, T. Brabletz, B. Reynolds, D. Steindler (2013)
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistanceEMBO Molecular Medicine, 5
-
Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells
J Immunol, 182
-
Jin Meng, Ping Li, Qing Zhang, Zhangru Yang, S. Fu (2014)
A radiosensitivity gene signature in predicting glioma prognostic via EMT pathwayOncotarget, 5
-
Frank Sleutels, Ronald Zwart, Denise Barlow (2002)
The non-coding Air RNA is required for silencing autosomal imprinted genesNature, 415
-
(2014)
Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomasOncotarget, 5
-
A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis
Cancer Res, 67
-
Junxia Zhang, Lei Han, Z. Bao, Yingyi Wang, Luyue Chen, Wei Yan, Shizhu Yu, P. Pu, Ning Liu, Y. You, T. Jiang, C. Kang (2013)
HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma.Neuro-oncology, 15 12
-
Ryan Thompson, Iosif Vardinogiannis, Thomas Gilmore (2013)
Identification of an NF-κB p50/p65-responsive site in the human MIR155HG promoterBMC Molecular Biology, 14
-
Kiranmai Gumireddy, D. Young, Xin Xiong, J. Hogenesch, Qihong Huang, A. Deiters (2008)
Small-molecule inhibitors of microrna miR-21 function.Angewandte Chemie, 47 39
-
V. Kumar, Priyanka Sehgal, Balram Thota, Shilpa Patil, V. Santosh, P. Kondaiah (2014)
Insulin like growth factor binding protein 4 promotes GBM progression and regulates key factors involved in EMT and invasionJournal of Neuro-Oncology, 116
-
Wei-Yi Cheng, J. Kandel, D. Yamashiro, P. Canoll, D. Anastassiou (2012)
A Multi-Cancer Mesenchymal Transition Gene Expression Signature Is Associated with Prolonged Time to Recurrence in GlioblastomaPLoS ONE, 7
-
Felipe Beckedorff, M. Amaral, C. DeOcesano-Pereira, S. Verjovski-Almeida (2013)
Long non-coding RNAs and their implications in cancer epigeneticsBioscience Reports, 33
-
Yimin Wu, M. Siadaty, M. Berens, G. Hampton, D. Theodorescu (2008)
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migrationOncogene, 27
-
W. Tam (2001)
Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA.Gene, 274 1-2
-
W. Tam, D. Ben-yehuda, W. Hayward (1997)
bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNAMolecular and Cellular Biology, 17
-
Qinyan Yin, Xia Wang, J. McBride, Claire Fewell, E. Flemington (2008)
B-cell Receptor Activation Induces BIC/miR-155 Expression through a Conserved AP-1 Element*Journal of Biological Chemistry, 283
-
D. Sarrió, S. Rodríguez-Pinilla, D. Hardisson, A. Cano, G. Moreno-Bueno, J. Palacios (2008)
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype.Cancer research, 68 4
-
W. Kong, Huan Yang, Lili He, Jian-jun Zhao, D. Coppola, W. Dalton, J. Cheng (2008)
MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoAMolecular and Cellular Biology, 28
-
M. Rossi, F. Antonangeli (2014)
LncRNAs: New Players in Apoptosis ControlInternational Journal of Cell Biology, 2014
-
K. Vargova, N. Čuřík, P. Burda, Petra Bašová, V. Kulvait, V. Pospíšil, F. Savvulidi, J. Kokavec, E. Nečas, A. Berková, P. Obrtlíková, J. Karban, M. Mraz, Š. Pospíšilová, J. Mayer, M. Trněný, J. Zavadil, T. Stopka (2011)
MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia.Blood, 117 14
-
A. Berg, B. Kroesen, K. Kooistra, D. Jong, J. Briggs, T. Blokzijl, Susan Jacobs, J. Kluiver, A. Diepstra, E. Maggio, S. Poppema (2002)
High expression of B‐cell receptor inducible gene BIC in all subtypes of Hodgkin lymphomaGenes, 37
-
M. Parisien, F. Major (2008)
The MC-Fold and MC-Sym pipeline infers RNA structure from sequence dataNature, 452
-
P. Eis, W. Tam, Liping Sun, A. Chadburn, Zongdong Li, Mario Gomez, E. Lund, J. Dahlberg (2005)
Accumulation of miR-155 and BIC RNA in human B cell lymphomas.Proceedings of the National Academy of Sciences of the United States of America, 102 10
- Publisher
- Oxford University Press
- Copyright
- © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected]
- ISSN
- 1522-8517
- eISSN
- 1523-5866
- DOI
- 10.1093/neuonc/nox017
- pmid
- 28371892
- Publisher site
- See Article on Publisher Site
Abstract
AbstractBackgroundMIR155 host gene (MIR155HG) is a long noncoding RNA that has been considered as the primary micro (mi)RNA of miR-155. MIR155HG plays an essential role in hematopoiesis, inflammation, and tumorigenesis. Our study investigated the clinical significance, biological function, mechanisms, and small-molecule inhibitors of the MIR155HG/miR-155 axis in glioma.MethodsWe analyzed the expression of the MIR155HG/miR-155 axis and the correlation with glioma grade and patient survival using 2 different glioma gene expression datasets. Biological significance was elucidated through a series of in vitro and in vivo experiments. Furthermore, we conducted a high-throughput screening for small molecules to identify a potential inhibitor of the MIR155HG/miR-155 axis.ResultsIncreased MIR155HG was associated with glioma grade, mesenchymal transition, and poor prognosis. Functionally, MIR155HG reduction by small interfering RNA inhibited cell proliferation, migration, invasion, and orthotopic glioma growth by repressing the generation of its derivatives miR-155-5p and miR-155-3p. Bioinformatics and luciferase reporter assays revealed that protocadherin 9 and protocadherin 7, which act as tumor suppressors by inhibiting the Wnt/β-catenin pathway, were direct targets of miR-155-5p and miR-155-3p, respectively. Finally, we identified NSC141562 as a potent small-molecule inhibitor of the MIR155HG/miR-155 axis.ConclusionsOur results demonstrate that the MIR155HG/miR-155 axis plays a critical role in facilitating glioma progression and serves as a prognostic factor for patient survival in glioblastoma. High-throughput screening indicated that the MIR155HG/miR-155 axis inhibitor NSC141562 may be a useful candidate anti-glioma drug.
Journal
Neuro-Oncology – Oxford University Press
Published: Sep 1, 2017