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Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism... Downloaded from genesdev.cshlp.org on November 22, 2021 - Published by Cold Spring Harbor Laboratory Press Raf induces TGF production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells 1 3 2 1 1 Kerstin Lehmann, Elzbieta Janda, Christophe E. Pierreux, Marjatta Ryto ¨ maa, Almut Schulze, 4 2 3 1,5 Martin McMahon, Caroline S. Hill, Hartmut Beug, and Julian Downward 1 2 Signal Transduction and Developmental Signaling Laboratories, Imperial Cancer Research Fund, London WC2A 3PX, UK; 3 4 Institute of Molecular Pathology, A-1030 Vienna, Austria; Cancer Research Institute, UCSF/Mt. Zion Cancer Center, San Francisco, California 94115-0128, USA c-Raf-1 is a major effector of Ras proteins, responsible for activation of the ERK MAP kinase pathway and a critical regulator of both normal growth and oncogenic transformation. Using an inducible form of Raf in MDCK cells, we have shown that sustained activation of Raf alone is able to induce the transition from an epithelial to a mesenchymal phenotype. Raf promoted invasive growth in collagen gels, a characteristic of malignant cells; this was dependent on the operation of an autocrine loop involving TGF, whose secretion was induced by Raf. TGF induced growth inhibition and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.181700
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Abstract

Downloaded from genesdev.cshlp.org on November 22, 2021 - Published by Cold Spring Harbor Laboratory Press Raf induces TGF production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells 1 3 2 1 1 Kerstin Lehmann, Elzbieta Janda, Christophe E. Pierreux, Marjatta Ryto ¨ maa, Almut Schulze, 4 2 3 1,5 Martin McMahon, Caroline S. Hill, Hartmut Beug, and Julian Downward 1 2 Signal Transduction and Developmental Signaling Laboratories, Imperial Cancer Research Fund, London WC2A 3PX, UK; 3 4 Institute of Molecular Pathology, A-1030 Vienna, Austria; Cancer Research Institute, UCSF/Mt. Zion Cancer Center, San Francisco, California 94115-0128, USA c-Raf-1 is a major effector of Ras proteins, responsible for activation of the ERK MAP kinase pathway and a critical regulator of both normal growth and oncogenic transformation. Using an inducible form of Raf in MDCK cells, we have shown that sustained activation of Raf alone is able to induce the transition from an epithelial to a mesenchymal phenotype. Raf promoted invasive growth in collagen gels, a characteristic of malignant cells; this was dependent on the operation of an autocrine loop involving TGF, whose secretion was induced by Raf. TGF induced growth inhibition and

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Genes & Development – Unpaywall

Published: Oct 15, 2000

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