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- Publisher
- Annual Reviews
- Copyright
- Copyright © 2010 by Annual Reviews. All rights reserved
- Subject
- Review Articles
- ISSN
- 0066-4278
- eISSN
- 1545-1585
- DOI
- 10.1146/annurev-physiol-021909-135846
- pmid
- 20148674
- Publisher site
- See Article on Publisher Site
Abstract
Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong risk factor for the development of type 2 diabetes mellitus. Insulin resistance in the setting of obesity results from a combination of altered functions of insulin target cells and the accumulation of macrophages that secrete proinflammatory mediators. At the molecular level, insulin resistance is promoted by a transition in macrophage polarization from an alternative M2 activation state maintained by STAT6 and PPARs to a classical M1 activation state driven by NF-κB, AP1, and other signal-dependent transcription factors that play crucial roles in innate immunity. Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention.
Journal
Annual Review of Physiology – Annual Reviews
Published: Mar 17, 2010