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Dextranomeres in Hyaluronan (DiHA): A Promising Substance in Treating Vocal Cord Insufficiency

Dextranomeres in Hyaluronan (DiHA): A Promising Substance in Treating Vocal Cord Insufficiency The morphology of the rabbit vocal cord was studied after injecting a mixture of dextranomere microspheres in sodium hyaluronan solution (DiHA), two substances that are nonimmunogenic and biocompatible. DiHA is already in clinical use as a space filler in pediatric urology (Deflux R). Specimens from injected vocal cords were investigated by light microscopy at different time intervals up to 6 months after injection. On macroscopic examination a bulge was seen in the injected vocal cord, and on microscopic examination new fibrous connective tissue developed. Throughout the study a weak inflammatory reaction was observed, but no foreign body reaction. Hyaluronan disappeared from the injected site within 1 week, but the dextranomeres remained and were recovered intact up to 6 months after injection. The dextranomeres recruited fibroblasts that generated new collagen, resulting in endogenous soft tissue augmentation. It is conceivable that DiHA may become a useful injection material for treatment of vocal cord insufficiency. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Laryngoscope Wiley

Dextranomeres in Hyaluronan (DiHA): A Promising Substance in Treating Vocal Cord Insufficiency

Hallén, Lars; Dahlqvist, Åke; Laurent, Claude
The Laryngoscope , Volume 108 (3) – Jan 1, 1998
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References (36)

Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services
ISSN
0023-852X
eISSN
1531-4995
DOI
10.1097/00005537-199803000-00015
Publisher site
See Article on Publisher Site

Abstract

The morphology of the rabbit vocal cord was studied after injecting a mixture of dextranomere microspheres in sodium hyaluronan solution (DiHA), two substances that are nonimmunogenic and biocompatible. DiHA is already in clinical use as a space filler in pediatric urology (Deflux R). Specimens from injected vocal cords were investigated by light microscopy at different time intervals up to 6 months after injection. On macroscopic examination a bulge was seen in the injected vocal cord, and on microscopic examination new fibrous connective tissue developed. Throughout the study a weak inflammatory reaction was observed, but no foreign body reaction. Hyaluronan disappeared from the injected site within 1 week, but the dextranomeres remained and were recovered intact up to 6 months after injection. The dextranomeres recruited fibroblasts that generated new collagen, resulting in endogenous soft tissue augmentation. It is conceivable that DiHA may become a useful injection material for treatment of vocal cord insufficiency.

Journal

The Laryngoscope – Wiley

Published: Jan 1, 1998

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