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- Publisher
- Wiley
- Copyright
- © Australasian Society for Immunology Inc.
- ISSN
- 0818-9641
- eISSN
- 1440-1711
- DOI
- 10.1038/icb.2010.137
- Publisher site
- See Article on Publisher Site
Abstract
Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self‐tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3+ Tregs and to what extent they are similar to or different from the murine counterparts. We also discuss important issues that remain to be addressed in the field to better understand the pathophysiology of autoimmune disease and to build solid basis for immunotherapies targeting FoxP3+ Tregs.
Journal
Immunology & Cell Biology – Wiley
Published: Mar 1, 2011
Keywords: ; ; ; ;