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Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and Residual Bodies/Phagosomes During Spermatogenesis in the Rat Testis

Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and... Downloaded from https://academic.oup.com/endo/article/157/4/1644/2351145 by DeepDyve user on 15 July 2021 ORIGINAL RESEARCH Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and Residual Bodies/Phagosomes During Spermatogenesis in the Rat Testis Elizabeth I. Tang, Will M. Lee, and C. Yan Cheng The Mary M. Wohlford Laboratory for Male Contraceptive Research (E.I.T., C.Y.C.), Center for Biomedical Research, Population Council, New York, New York 10065; and School of Biological Sciences (W.M.L.), The University of Hong Kong, Hong Kong, China Germ cell transport across the seminiferous epithelium during spermatogenesis requires the in- tricate coordination of cell junctions, signaling proteins, and both actin- and microtubule (MT)- based cytoskeletons. Although the involvement of cytoskeletons in germ cell transport has been suggested, the precise mechanism(s) remains elusive. Based on growing evidence that actin and MT interactions underlie fundamental cellular processes, such as cell motility, it is unlikely that actin- and MT-based cytoskeletons work independently to regulate germ cell transport in the testis. Using rats treated with adjudin, a potential male contraceptive that disrupts spermatid adhesion and transport in the testis, as a study model, we show herein that actin- and MT-based cytoskeletons are both necessary for transport of spermatids and residual bodies/phagosomes across the semi- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Endocrinology Unpaywall

Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and Residual Bodies/Phagosomes During Spermatogenesis in the Rat Testis

Tang, Elizabeth I.; Lee, Will M.; Yan Cheng, C.
Endocrinology – Jan 1, 2016
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References (64)

Publisher
Unpaywall
ISSN
0013-7227
DOI
10.1210/en.2015-1962
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Abstract

Downloaded from https://academic.oup.com/endo/article/157/4/1644/2351145 by DeepDyve user on 15 July 2021 ORIGINAL RESEARCH Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and Residual Bodies/Phagosomes During Spermatogenesis in the Rat Testis Elizabeth I. Tang, Will M. Lee, and C. Yan Cheng The Mary M. Wohlford Laboratory for Male Contraceptive Research (E.I.T., C.Y.C.), Center for Biomedical Research, Population Council, New York, New York 10065; and School of Biological Sciences (W.M.L.), The University of Hong Kong, Hong Kong, China Germ cell transport across the seminiferous epithelium during spermatogenesis requires the in- tricate coordination of cell junctions, signaling proteins, and both actin- and microtubule (MT)- based cytoskeletons. Although the involvement of cytoskeletons in germ cell transport has been suggested, the precise mechanism(s) remains elusive. Based on growing evidence that actin and MT interactions underlie fundamental cellular processes, such as cell motility, it is unlikely that actin- and MT-based cytoskeletons work independently to regulate germ cell transport in the testis. Using rats treated with adjudin, a potential male contraceptive that disrupts spermatid adhesion and transport in the testis, as a study model, we show herein that actin- and MT-based cytoskeletons are both necessary for transport of spermatids and residual bodies/phagosomes across the semi-

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Endocrinology – Unpaywall

Published: Jan 1, 2016

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