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- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Springer-Verlag
- Subject
- Medicine & Public Health; Nephrology ; Oncology ; Urology/Andrology
- ISSN
- 0724-4983
- eISSN
- 1433-8726
- DOI
- 10.1007/s00345-008-0294-8
- pmid
- 18594826
- Publisher site
- See Article on Publisher Site
Abstract
World J Urol (2008) 26:637–642 DOI 10.1007/s00345-008-0294-8 O R I G IN AL ARTI CL E Loss of galectin-3 expression correlates with clear cell renal carcinoma progression and reduced survival Axel S. Merseburger Æ Mario W. Kramer Æ Jo ¨ rg Hennenlotter Æ Ju ¨ rgen Serth Æ Stephan Kruck Æ Alfredo Gracia Æ Arnulf Stenzl Æ Markus A. Kuczyk Received: 5 November 2007 / Accepted: 4 June 2008 / Published online: 2 July 2008 Springer-Verlag 2008 Abstract unfavourable long-term prognosis in univariate Kaplan– Objectives Galectin-3 is a member of the glycoprotein Meier (P \ 0.007) and multivariate Cox proportional hazard family, actively involved in various biological interactions analyses (P \ 0.04). Univariate analysis could demonstrate including cell growth, cell adhesion, cell differentiation an association with tumor-specific death with decreased and apoptosis. The aim of this study was to analyze the galectin-3 expression, whereas multivariate analysis failed expression of galectin-3 in clear cell renal carcinoma and to prove the aforementioned observation. to assess its prognostic significance. Conclusion Our results suggest that a loss of galectin-3 Methods The expression of galectin-3 was analyzed by expression is involved in renal carcinogenesis. immunohistochemistry in 149 clear cell renal carcinomas. The levels were
Journal
World Journal of Urology – Springer Journals
Published: Jul 2, 2008