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Marker effects and the nature of the recombination event at the his1 locus of Saccharomyces cerevisiae

Marker effects and the nature of the recombination event at the his1 locus of Saccharomyces... Analysis of unselected and selected (prototroph-containing) tetrads, carrying two or three alleles of the his1 locus in yeast, led to the following conclusions: (1) Conversion at this locus is strongly polarized and asymmetrical. (2) In cases where a crossover is separated from a converted marker by an unconverted segment, these effects are parts of the same event. (3) The distribution of the various classes of tetrad with a crossover associated with conversion at his1 shows that the crossover is at the variable end of the event within the gene. (4) Reciprocal intragenic recombination results from restoration correction in crossover events which end between the alleles. Its occurrence is marker dependent, not distance dependent. (5) A deficiency in reciprocal intragenic recombination is interpreted as an allele-specific disparity in the ratio of conversion to restoration. (6) Marker effects are interpreted in terms of reciprocal influence of markers on each other's correction from heteroduplex, and of interference by heterozygosity with the migration of the cross-strand exchange. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Genetics Springer Journals

Marker effects and the nature of the recombination event at the his1 locus of Saccharomyces cerevisiae

Savage, E.; Hastings, P.
Current Genetics , Volume 3 (1) – Sep 21, 2004
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References (15)

Publisher
Springer Journals
Copyright
Copyright © 1981 by Springer-Verlag
Subject
Life Sciences; Microbial Genetics and Genomics; Microbiology; Biochemistry, general; Cell Biology; Plant Sciences; Proteomics
ISSN
0172-8083
eISSN
1432-0983
DOI
10.1007/BF00419579
Publisher site
See Article on Publisher Site

Abstract

Analysis of unselected and selected (prototroph-containing) tetrads, carrying two or three alleles of the his1 locus in yeast, led to the following conclusions: (1) Conversion at this locus is strongly polarized and asymmetrical. (2) In cases where a crossover is separated from a converted marker by an unconverted segment, these effects are parts of the same event. (3) The distribution of the various classes of tetrad with a crossover associated with conversion at his1 shows that the crossover is at the variable end of the event within the gene. (4) Reciprocal intragenic recombination results from restoration correction in crossover events which end between the alleles. Its occurrence is marker dependent, not distance dependent. (5) A deficiency in reciprocal intragenic recombination is interpreted as an allele-specific disparity in the ratio of conversion to restoration. (6) Marker effects are interpreted in terms of reciprocal influence of markers on each other's correction from heteroduplex, and of interference by heterozygosity with the migration of the cross-strand exchange.

Journal

Current Genetics – Springer Journals

Published: Sep 21, 2004

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