Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/gpr55-a-new-member-of-the-cannabinoid-receptor-clan-Pw2RjLXDVS
References (15)
-
E. Ryberg, N. Larsson, S. Sjögren, S. Hjorth, Nils-Olov Hermansson, J. Leonova, T. Elebring, K. Nilsson, T. Drmota, P. Greasley (2007)
The orphan receptor GPR55 is a novel cannabinoid receptorBritish Journal of Pharmacology, 152
-
R. Pertwee (2005)
The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoidsThe AAPS Journal, 7
-
R. Pertwee (2005)
Pharmacological actions of cannabinoids.Handbook of experimental pharmacology, 168
-
R. Mechoulam, S. Ben-Shabat, L. Hanuš, M. Ligumsky, N. Kaminski, A. Schatz, A. Gopher, S. Almog, B. Martin, D. Compton, R. Pertwee, G. Griffin, M. Bayewitch, J. Barg, Z. Vogel (1995)
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.Biochemical pharmacology, 50 1
-
R. Pertwee (2004)
Novel Pharmacological Targets for CannabinoidsCurrent Neuropharmacology, 2
-
(2005)
Molecular identification of GPR 55 as a third G protein - coupled receptor responsive to cannabinoid ligands -
R. Pertwee (2006)
Cannabinoid pharmacology: the first 66 yearsBritish Journal of Pharmacology, 147
-
(2001)
Identification of modulators of GPR 55 activity -
D. Baker, G. Pryce, Wayne Davies, C. Hiley (2006)
In silico patent searching reveals a new cannabinoid receptor.Trends in pharmacological sciences, 27 1
-
(2004)
Screening assays for cannabinoid - ligand type modulators of GPR 55 -
T. Sugiura, S. Kondo, A. Sukagawa, S. Nakane, A. Shinoda, K. Itoh, A. Yamashita, K. Waku (1995)
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.Biochemical and biophysical research communications, 215 1
-
S. Sjögren, S. Hjorth, N. Larsson, A. Åstrand, A. Lindblom, E. Ryberg, P. Greasley (2007)
A new receptor for cannabinoid ligands -
W. Devane, L. Hanuš, A. Breuer, R. Pertwee, L. Stevenson, G. Griffin, D. Gibson, A. Mandelbaum, A. Etinger, R. Mechoulam (1992)
Isolation and structure of a brain constituent that binds to the cannabinoid receptor.Science, 258 5090
-
A. Howlett, F. Barth, T. Bonner, G. Cabral, P. Casellas, W. Devane, C. Felder, M. Herkenham, K. Mackie, B. Martin, R. Mechoulam, R. Pertwee (2002)
International Union of Pharmacology. XXVII. Classification of Cannabinoid ReceptorsPharmacological Reviews, 54
-
A. Thomas, G. Baillie, A. Phillips, R. Razdan, R. Ross, R. Pertwee (2007)
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitroBritish Journal of Pharmacology, 150
- Publisher
- Wiley
- Copyright
- 2007 British Pharmacological Society
- ISSN
- 0007-1188
- eISSN
- 1476-5381
- DOI
- 10.1038/sj.bjp.0707464
- pmid
- 17876300
- Publisher site
- See Article on Publisher Site
Abstract
In this issue of the British Journal of Pharmacology, Ryberg et al. present convincing in vitro evidence that the orphan GPCR, GPR55, is a cannabinoid receptor. GPR55 was activated by a range of plant, synthetic and endogenous cannabinoids and blocked by the non‐psychoactive phytocannabinoid, cannabidiol. Their experiments have revealed several differences between the pharmacology of GPR55 and the established cannabinoid CB1 and CB2 receptors. For example, the CB1 receptor antagonist, AM251, activated GPR55 and the main psychoactive constituent of cannabis, Δ9‐tetrahydrocannabinol, displayed greater efficacy at GPR55 than at CB1 or CB2 receptors. They also compared the distribution of GPR55 and CB1 mRNA in mouse and report that GPR55 couples to Gα13, that it is activated by virodhamine, palmitoylethanolamide and oleoylethanolamide, and that virodhamine displays relatively high efficacy as a GPR55 agonist. Still to be identified are the main roles played by GPR55 in health and disease and any potential therapeutic benefits of activating or blocking this receptor. British Journal of Pharmacology (2007) 152, 984–986; doi:10.1038/sj.bjp.0707464; published online 17 September 2007
Journal
British Journal of Pharmacology – Wiley
Published: Dec 1, 2007