Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Dopamine ligands and the stimulus effects of amphetamine: animal models versus human laboratory data

Dopamine ligands and the stimulus effects of amphetamine: animal models versus human laboratory data Studies with laboratory animals have consistently demonstrated a role for dopamine in mediating the discriminative stimulus (i.e., interoceptive) effects of amphetamine. For example, D 2 dopamine agonists mimic the discriminative stimulus effects of amphetamine and D 1 and D 2 dopamine antagonists generally block them. The discriminative stimulus effects of drugs in animals are believed to parallel their subjective effects in humans. Therefore, it is often assumed that dopamine plays a role in amphetamine-induced subjective effects in humans and it would be reasonable to expect that dopamine antagonists would block the subjective effects of amphetamine. Few studies have tested this hypothesis directly, and those that have have yielded inconsistent results. This paper will review data regarding the effects of dopamine agonists and antagonists on the discriminative stimulus effects of amphetamine in animals and its subjective effects in humans. Possible explanations for the discrepancies between animal and human data will be discussed, and classical assumptions underlying the use of animal models of drug effects will be examined. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Dopamine ligands and the stimulus effects of amphetamine: animal models versus human laboratory data

Download PDF
12 pages

Loading next page...
 
/lp/springer-journals/dopamine-ligands-and-the-stimulus-effects-of-amphetamine-animal-models-PtpRFmMXTE

References (85)

Publisher
Springer Journals
Copyright
Copyright © 1997 by Springer-Verlag Berlin Heidelberg
Subject
Legacy
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/s002130050207
Publisher site
See Article on Publisher Site

Abstract

Studies with laboratory animals have consistently demonstrated a role for dopamine in mediating the discriminative stimulus (i.e., interoceptive) effects of amphetamine. For example, D 2 dopamine agonists mimic the discriminative stimulus effects of amphetamine and D 1 and D 2 dopamine antagonists generally block them. The discriminative stimulus effects of drugs in animals are believed to parallel their subjective effects in humans. Therefore, it is often assumed that dopamine plays a role in amphetamine-induced subjective effects in humans and it would be reasonable to expect that dopamine antagonists would block the subjective effects of amphetamine. Few studies have tested this hypothesis directly, and those that have have yielded inconsistent results. This paper will review data regarding the effects of dopamine agonists and antagonists on the discriminative stimulus effects of amphetamine in animals and its subjective effects in humans. Possible explanations for the discrepancies between animal and human data will be discussed, and classical assumptions underlying the use of animal models of drug effects will be examined.

Journal

Psychopharmacology – Springer Journals

Published: Mar 1, 1997

There are no references for this article.