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References (17)
-
T. Perry, David Hardwick, Gordon Dixon, Clarisse Dolman, Shirley Hansen (1965)
HYPERMETHIONINEMIA: A METABOLIC DISORDER ASSOCIATED WITH CIRRHOSIS, ISLET CELL HYPERPLASIA, AND RENAL TUBULAR DEGENERATION.Pediatrics, 36
-
J. Flexner, L. Flexner, E. Stellar (1963)
Memory in Mice as Affected by Intracerebral PuromycinScience, 141
-
S. Moore, D. Spackman, W. Stein (1958)
Automatic recording apparatus for use in the chromatography of amino acids.Federation proceedings, 17 4
-
Hwa Wang, H. Waisman (1961)
Experimental Phenylketonuria in Rats.∗Proceedings of the Society for Experimental Biology and Medicine, 108
-
T. Gerritsen, M. Rehberg, H. Waisman (1965)
On the determination of free amino acids in serumAnalytical Biochemistry, 11
-
S. Appel (1966)
Inhibition of brain protein synthesis: an approach to the biochemical basis of neurological dysfunction in the amino-acidurias.Transactions of the New York Academy of Sciences, 29 1
-
S. Roberts, B. Morelos (1965)
REGULATION OF CEREBRAL METABOLISM OF AMINO ACIDS—IV. INFLUENCE OF AMINO ACID LEVELS ON LEUCINE UPTAKE, UTILIZATION AND INCORPORATION INTO PROTEIN IN VZVO *Journal of Neurochemistry, 12
-
L. Pauling (1968)
Orthomolecular PsychiatryScience, 160
-
K. Neame (1964)
EFFECT OF AMINO ACIDS ON UPTAKE OF l‐HISTIDINE BY RAT BRAIN SLICESJournal of Neurochemistry, 11
-
N. Carson, D. Cusworth, C. Dent, C. Field, D. Neill, R. Westall (1963)
Homocystinuria: A new inborn error of Metabolism associated with Mental DeficiencyArchives of Disease in Childhood, 38
-
Theo Gerritsen, James Vaughn, H. Waisman (1962)
The identification of homocystine in the urine.Biochemical and biophysical research communications, 9
-
E. Geller, A. Yuwiler (1967)
BRAIN AMINE DECREASE IN LEUCINE‐FED RATS *Journal of Neurochemistry, 14
-
B. Agranoff, R. Davis, J. Brink (1965)
Memory fixation in the goldfish.Proceedings of the National Academy of Sciences of the United States of America, 54 3
-
G. Guroff, W. King, S. Undenfriend (1961)
The uptake of tyrosine by rat brain in vitro.The Journal of biological chemistry, 236
-
G. Guroff, S. Udenfriend (1962)
Studies on aromatic amino acid uptake by rat brain in vivo. Uptake of phenylalanine and of tryptophan; inhibition and stereoselectivity in the uptake of tyrosine by brain and muscle.The Journal of biological chemistry, 237
-
S. Barondes, H. Cohen (1966)
Puromycin Effect on Successive Phases of Memory StorageScience, 151
-
S. Mudd, J. Finkelstein, F. Irreverre, L. Laster (1964)
Homocystinuria: An Enzymatic DefectScience, 143
- Publisher
- Wiley
- Copyright
- Copyright © 1969 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- DOI
- 10.1111/j.1471-4159.1969.tb06458.x
- Publisher site
- See Article on Publisher Site
Abstract
Abstract— —High circulating levels of l‐methionine produced by inclusion in the diet or parenteral injection of the amino acid caused alterations in the free amino acid pattern of liver and brain tissues. Acute effects following l‐methionine injection were more pronounced than those following long term feeding where adaptation played a role. The net effect following parenteral injection was to increase the total free amino acids of liver while decreasing those of brain. Individually, hepatic levels of aspartic acid, threonine, serine, glutamine, glutamic acid, glycine, and alanine were depressed while levels of taurine, cystathionine, methionine, lysine, and ornithine were markedly elevated. Brain levels of aspartic acid, threonine, serine, glutamic acid, glycine, alanine, and γ‐aminobutyric acid were markedly depressed and increased levels of cystathionine, methionine, lysine, and glutamine were observed. A generalized aminoaciduria occurred shortly after excessive methionine intake. Disruption of the free amino acid pools was of two kinds. The first depended on the continued presence of excess l‐methionine, the second did not.
Journal
Journal of Neurochemistry – Wiley
Published: May 1, 1969