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Increased serum concentration of soluble HLA‐DR antigens in HIV infection and following transplantation

Increased serum concentration of soluble HLA‐DR antigens in HIV infection and following... Abstract: HLA class I and class II antigens circulate in serum as soluble molecules. Increased concentrations of soluble HLA class I molecules have been demonstrated in viral diseases, in rejection episodes following organ transplantation and in graft versus host disease. To explore the possibility of a variation of the serum concentrations of soluble HLA class II molecules in the same pathologic conditions we developed a double determinant immune assay that detects whole soluble HLA‐DR molecules (sHLA‐DR). The mean level of sHLA‐DR antigens in sera from 23 healthy individuals was 0.64±0.72 μg/ml. Elevated serum concentrations of sHLA‐DR molecules were detected in sera from HIV infected patients in CDC2/3 and in CDC4C1 stages (2.0±1.7 m̀g/ml and 4.6±1.7 m̀g/ml, respectively), in sera from patients affected by acute rejection after liver transplantation (5.3±3.7 μg/ml) and in sera from patients affected by severe acute graft versus host disease following bone marrow transplantation (8.8±3.1 μg/ml). The increase of sHLA‐DR molecules in these sera significantly correlated with the elevation of soluble HLA class I antigens (P=0.0004). The reported data suggest that both soluble HLA class I and class II molecules serum levels increase during viral infections and strong immune reactions and could suggest the involvement of these molecules in immunoregulation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Tissue Antigens Wiley

Increased serum concentration of soluble HLA‐DR antigens in HIV infection and following transplantation

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References (34)

Publisher
Wiley
Copyright
Copyright © 1995 Munksgaard
ISSN
0001-2815
eISSN
1399-0039
DOI
10.1111/j.1399-0039.1995.tb02487.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: HLA class I and class II antigens circulate in serum as soluble molecules. Increased concentrations of soluble HLA class I molecules have been demonstrated in viral diseases, in rejection episodes following organ transplantation and in graft versus host disease. To explore the possibility of a variation of the serum concentrations of soluble HLA class II molecules in the same pathologic conditions we developed a double determinant immune assay that detects whole soluble HLA‐DR molecules (sHLA‐DR). The mean level of sHLA‐DR antigens in sera from 23 healthy individuals was 0.64±0.72 μg/ml. Elevated serum concentrations of sHLA‐DR molecules were detected in sera from HIV infected patients in CDC2/3 and in CDC4C1 stages (2.0±1.7 m̀g/ml and 4.6±1.7 m̀g/ml, respectively), in sera from patients affected by acute rejection after liver transplantation (5.3±3.7 μg/ml) and in sera from patients affected by severe acute graft versus host disease following bone marrow transplantation (8.8±3.1 μg/ml). The increase of sHLA‐DR molecules in these sera significantly correlated with the elevation of soluble HLA class I antigens (P=0.0004). The reported data suggest that both soluble HLA class I and class II molecules serum levels increase during viral infections and strong immune reactions and could suggest the involvement of these molecules in immunoregulation.

Journal

Tissue Antigens – Wiley

Published: Aug 1, 1995

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