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References (34)
-
McGeer McGeer, Itagaki Itagaki, Akiyama Akiyama, McGeer McGeer (1988a)
Rate of cell death in parkinsonism indicates active neuropathological processAnn Neurol, 24
-
Graham Graham (1978)
Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinonesMol Pharmacol, 14
-
Garris Garris, Ciolowski Ciolowski, Pastoer Pastoer, Wrightman Wrightman (1994)
Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brainJ Neurosci, 14
-
Montine Montine, Farris Farris, Graham Graham (1995)
Covalent cross‐linking of neurofilament proteins by oxidized catechols as a potential mechanism of Lewy body formationJ Neuropathol Exp Neurol, 54
-
Hastings Hastings, Zigmond Zigmond (1994)
Identification of catechol‐protein conjugates in neostriatal slices incubated with (3H) dopamine: Impact of ascorbic acid and glutathioneJ Neurochem, 63
-
Tse Tse, McCreery McCreery, Adams Adams (1976)
Potential oxidative pathways of brain catecholaminesJ Med Chem, 19
-
Forno Forno (1996)
Neuropathology of Parkinson's diseaseJ Neuropathol Exp Neurol, 55
-
Fiszer Fiszer, Mix Mix, Fredrikson Fredrikson, Kostulas Kostulas, Olsson Olsson, Link Link (1994b)
Gamma‐delta +T cells are increased in patients with Parkinson's diseaseJ Neurol Sci, 121
-
Paz Paz, Fluckiger Fluckiger, Boak Boak, Kagan Kagan (1991)
Specific detection of quinoproteins by redox‐cycling stainingJ Biol Chem, 266
-
Yamada Yamada, McGeer McGeer, McGeer McGeer (1992)
Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteinsActa Neuropathol (Berl), 84
-
Carvey Carvey, McRae McRae, Lint Lint, Ptak Ptak, Lo Lo, Goetz Goetz, Klawans Klawans (1991)
The potential use of a dopamine neuron antibody and a striatal‐derived neurotrophic factor as diagnostic markers in Parkinson's diseaseNeurology, 41
-
Saito Saito, Nagao Nagao, Okabe Okabe, Saito Saito (1996)
Neurochemical and histochemical evidence for an abnormal catecholamine metabolism in the cerebral cortex of the Long‐Evans Cinnamon rat before excessive copper accumulation in the brainNeurosci Lett, 216
-
Abramsky Abramsky, Litvin Litvin (1978)
A possible mechanism in the pathogenesis of Parkinson's disease and schizophreniaPerspect Biol Med, 22
-
Berman Berman, Zigmond Zigmond, Hastings Hastings (1996)
Modification of dopamine transporter function: Effect of reactive oxygen species and dopamineJ Neurochem, 67
-
Emile Emile, Pouplard Pouplard, Bossu von Nieuwenhuyse Bossu von Nieuwenhuyse, Bernat‐Viallet Bernat‐Viallet (1980)
Maladie de Parkinson, dysautonomie et auto‐anticorps diriges contre les neurones sympathetiquesRev Neurol (Paris), 136
-
Bokor Bokor, Farago Farago, Garam Garam, Malatwszky Malatwszky, Schnabel Schnabel (1993)
Antibody dependent cell‐mediated cytotoxicity (ADCC) in Parkinson's diseaseJ Neurol Sci, 115
-
Kuhn Kuhn, Muller Muller, Nastos Nastos, Poehlau Poehlau (1997)
The neuroimmune hypothesis in Parkinson's diseaseRev Neurosci, 8
-
Fiszer Fiszer, Mix Mix, Frederikson Frederikson, Kostulas Kostulas, Link Link (1994a)
Parkinson's disease and immunological abnormalities: Increase of HLA‐DR expression and monocytes in cerebrospinal fluid and of CDR45RO+ T cells in peripheral bloodActa Neurol Scand, 90
-
Potempa Potempa, Korvus Korvus, Travis Travis (1994)
The serpin superfamily of proteinase inhibitors: Structure, function and regulationJ Biol Chem, 269
-
Mogi Mogi, Harada Harada, Kondo Kondo, Reiderer Reiderer, Nagatsu Nagatsu (1995)
Brain beta‐2‐ microglobulin levels are elevated in the striatum in Parkinson's diseaseJ Neural Trans. (P‐D Section), 9
-
Spritz Spritz, Ho Ho, Furumura Furumura, Hearing Hearing (1997)
Mutational analysis of copper binding by human tyrosinaseJ Invest Dermatol, 109
-
Friedman Friedman, Kaufman Kaufman (1965)
3,4‐dihydroxyphenylethylamine‐b‐hydroxylase. Physical properties, copper content, and role of copper in the catalytic activityJ Biol Chem, 240
-
Blaes Blaes, Jost Jost, Bellon Bellon, Klotz Klotz (1996)
Autoantibodies against substantia nigra in Parkinson's disease‐correlations with autonomic dysfunction (abstract)Mov Disord, 11
-
Linert Linert, Herlinger Herlinger, Jameson Jameson, Kienzl Kienzl, Jellinger Jellinger, Youdim Youdim (1996)
Dopamine, 6‐hydroxydopamine, iron, and dioxygen—their mutual interactions and possible implication in the development of Parkinson's diseaseBiochim Biophys Acta, 1316
-
Berman Berman, Hastings Hastings (1997)
Inhibition of glutamate transport in synaptosomes by dopamine oxidation and reactive oxygen speciesJ Neurochem, 69
-
Graham Graham, Tiffany Tiffany, Bell Bell, Gutknecht Gutknecht (1978)
Autooxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6‐hydroxydopamine, and related components towards C1300 neuroblastoma cells in vitroMol Pharmacol, 14
-
McRae‐Degueurce McRae‐Degueurce, Gottfries Gottfries, Karlson Karlson, Svennerholm Svennerholm, Dahlstrom Dahlstrom (1986)
Antibodies in the CSF of a Parkinson patient recognizes neurons in rat mesencephalic regionsActa Physiol Scand, 126
-
Gerlach Gerlach, Double Double, Reiderer Reiderer, Hirsch Hirsch, Jellinger Jellinger, Jenner Jenner, Trautwein Trautwein, Youdim Youdim (1997)
Iron in the parkinsonian substantia nigraMov Disord, 12
-
McGeer McGeer, Itagaki Itagaki, Boyes Boyes, McGeer McGeer (1988b)
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brainsNeurology, 38
-
Barker Barker, Cahn Cahn (1988)
Parkinson's disease: an autoimmune processInt J Neurosci, 43
-
Miller Miller, Buettner Buettner, Aust Aust (1990)
Transition metals as catalysts of ‘autoxidation’ reactionsFree Radic Biol Med, 8
-
Spencer Spencer, Jenner Jenner, Halliwell Halliwell (1995)
Superoxide‐dependent depletion of reduced glutathione by L ‐dopa and dopamine. Relevance to Parkinson's diseaseNeuroreport, 6
-
Defazio Defazio, Dal Toso Dal Toso, Benvegnu Benvegnu, Minozzi Minozzi, Cananzi Cananzi, Leon Leon (1994)
Parkinsonian serum carries complement‐dependent toxicity for rat mesencephalic dopaminergic neurons in cultureBrain Res, 633
-
Graham Graham (1979)
On the significance and origin of neuromelaninArch Pathol Lab Med, 103
- Publisher
- Wiley
- Copyright
- Copyright © 1998 Wiley‐Liss, Inc.
- ISSN
- 0360-4012
- eISSN
- 1097-4547
- DOI
- 10.1002/(SICI)1097-4547(19980901)53:5<551::AID-JNR5>3.0.CO;2-8
- pmid
- 9726426
- Publisher site
- See Article on Publisher Site
Abstract
To determine whether specific antibodies are present in PD, we used an enzyme‐linked immunosorbant assay (ELISA) that identifies increased immunoglobulin (IgG) levels towards a synthetic substrate prepared by incubating ovalbumin with dopamine and copper sulfate. Altered absorption spectrum and specific chemical detection demonstrated quinone modification of the ovalbumin. This modified protein was demonstrated to react with serial dilutions of PD sera. A threshold dilution of 1:500 was subsequently used to screen sera from patients with PD (n = 21), amyotrophic lateral sclerosis (n = 7), Alzheimer's disease (n = 7) and other neurological disease controls (n = 7). The assay produced a positive result in 7/21 PD patients and 0/21 disease controls (P < 0.02, Kruskal–Wallis test). Further testing of sera from untreated PD patients (n = 6) identified one positive sample. Thus, a subset of Parkinson's disease (PD) patients has immunoglobulin (IgG) to ovalbumin modified by dopamine oxidation. The presence of antibody reactivity to quinone‐modified proteins could contribute to or amplify the inflammatory response in PD. J. Neurosci. Res. 53:551–558, 1998. © 1998 Wiley‐Liss, Inc.
Journal
Journal of Neuroscience Research – Wiley
Published: Sep 1, 1998