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- ISSN
- 0028-3878
- eISSN
- 1526-632X
- DOI
- 10.1212/01.WNL.0000145762.60562.5D
- Publisher site
- See Article on Publisher Site
Abstract
Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis B.A.C. Cree, MD, PhD, MCR; O. Khan, MD; D. Bourdette, MD; D.S. Goodin, MD; J.A. Cohen, MD; R.A. Marrie, MD; D. Glidden, PhD; B. Weinstock-Guttman, MD; D. Reich, PhD; N. Patterson, PhD; J.L. Haines, PhD; M. Pericak-Vance, PhD; C. DeLoa, BS; J.R. Oksenberg, PhD; and S.L. Hauser, MD Abstract—Background: African American (AA) individuals are thought to develop multiple sclerosis (MS) less frequently than Caucasian American (CA) individuals. Objective: To compare the clinical characteristics of AA and CA patients with MS. Methods: The clinical features of MS were compared in a large retrospective cohort of AA (n 375) and CA (n 427) subjects. Results: The proportion of women to men was similar in AA and CA subjects (81% [AA] vs 77% [CA]; p 0.122). There were no differences in the proportions of subjects with relapsing–remitting, secondary progressive, primary progres- sive, and progressive relapsing MS. The median time to diagnosis was 1 year after symptom onset in AA subjects and 2 years after symptom onset in CA subjects (p 0.0013). The age at onset was approximately 2.5 years later in AA than CA subjects (33.7 vs
Journal
Neurology – Wolters Kluwer Health
Published: Dec 1, 2004