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- Publisher
- Springer Journals
- Copyright
- Copyright © 2007 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature06322
- Publisher site
- See Article on Publisher Site
Abstract
The nutrient sensor molecule mTOR (mammalian target of rapamycin) is a kinase involved in the regulation of cell growth and proliferation. Its close links to the cell's energetics suggest that it might interact with the mitochondria, and a computational genomics study now confirms that it does. mTOR balances energy metabolism via transcriptional control of mitochondrial gene expression and oxidative function, with the transcriptional regulators PGC-1a and YY1 as mediators. This pathway opens new possibilities for therapeutic interventions in metabolic diseases in which mitochondrial activity is compromised.
Journal
Nature – Springer Journals
Published: Nov 29, 2007