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Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria

Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria RELATIVE protection against Plasmodium falciparum malaria afforded to heterozygous carriers of the sickle-cell gene is now the accepted mechanism for the high frequency of the gene in areas where malaria is (or was) common1–3. However, the cellular mechanisms whereby Hb S protects the red cell against the malarial parasite are still not fully understood. We have compared the rates of invasion and growth of P. falciparum in normal red cells and in those of individuals with the sickling disorders, in both aerobic conditions and conditions of reduced oxygen tension. As a result of these studies, we suggest a possible mechanism for the protection of sickle-cell heterozygotes against P. falciparum malaria. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria

PASVOL, G.; WEATHERALL, D. J.; WILSON, R. J. M.
Nature , Volume 274 (5672) – Aug 17, 1978
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References (8)

Publisher
Springer Journals
Copyright
Copyright © 1978 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/274701a0
Publisher site
See Article on Publisher Site

Abstract

RELATIVE protection against Plasmodium falciparum malaria afforded to heterozygous carriers of the sickle-cell gene is now the accepted mechanism for the high frequency of the gene in areas where malaria is (or was) common1–3. However, the cellular mechanisms whereby Hb S protects the red cell against the malarial parasite are still not fully understood. We have compared the rates of invasion and growth of P. falciparum in normal red cells and in those of individuals with the sickling disorders, in both aerobic conditions and conditions of reduced oxygen tension. As a result of these studies, we suggest a possible mechanism for the protection of sickle-cell heterozygotes against P. falciparum malaria.

Journal

Nature – Springer Journals

Published: Aug 17, 1978

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