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Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of Taxol

Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of Taxol Abstract RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, Promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells.Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells. [J Natl Cancer Inst 83:288–291, 1991] This content is only available as a PDF. Author notes Supported in pan by the Israel Cancer Association (I. Ringel) and by Public Health Service grant CA- 39821 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services (S. B. Horwitz). We thank Prof Francois Lavelle of Rhone-Poulenc Santi for providing RP 56976. © Oxford University Press http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JNCI: Journal of the National Cancer Institute Oxford University Press

Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of Taxol

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Publisher
Oxford University Press
Copyright
© Oxford University Press
ISSN
0027-8874
eISSN
1460-2105
DOI
10.1093/jnci/83.4.288
Publisher site
See Article on Publisher Site

Abstract

Abstract RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, Promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells.Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells. [J Natl Cancer Inst 83:288–291, 1991] This content is only available as a PDF. Author notes Supported in pan by the Israel Cancer Association (I. Ringel) and by Public Health Service grant CA- 39821 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services (S. B. Horwitz). We thank Prof Francois Lavelle of Rhone-Poulenc Santi for providing RP 56976. © Oxford University Press

Journal

JNCI: Journal of the National Cancer Institute – Oxford University Press

Published: Feb 20, 1991

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