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Acute Effect of Castration on Serum FSH and LH in the Adult Woman

Acute Effect of Castration on Serum FSH and LH in the Adult Woman Abstract The sequence of changes in serum FSH and LH levels immediately following surgical or roentgen castration has been measured by differential radioimmunoassays. A prompt and marked rise in serum FSH and LH occurred within a few days after ablation of ovarian function in all subjects, except one who had been pregnant prior to castration and another who had received fluoxymesterone (100 mg/day). Elevation of serum FSH and LH to values equal to or greater than 100 milli-International Units (IRP-HMG) per ml was attained within approximately 20 days after surgical castration and 30–40 days after initiation of roentgen castration. The pattern of increase in FSH release following castration did not differ noticeably from the pattern of increase in LH release. Stilbestrol, in a daily dosage of either 0.1 or 0.2 mg, administered to 3 subjects, had either a slight effect or no effect on these elevated levels of serum FSH and LH post castration. In a dose of 1.0 mg, stilbestrol, administered to one subject, substanstantially reduced the elevated serum FSH and LH, but failed to return these values to precastration levels. This content is only available as a PDF. Author notes Supported by NIH Grant AM 11214, USPHS RCDA AM 7735, and Ford Foundation Grant 67–514. Copyright © 1970 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

Acute Effect of Castration on Serum FSH and LH in the Adult Woman

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Publisher
Oxford University Press
Copyright
Copyright © 1970 by The Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
DOI
10.1210/jcem-31-1-43
Publisher site
See Article on Publisher Site

Abstract

Abstract The sequence of changes in serum FSH and LH levels immediately following surgical or roentgen castration has been measured by differential radioimmunoassays. A prompt and marked rise in serum FSH and LH occurred within a few days after ablation of ovarian function in all subjects, except one who had been pregnant prior to castration and another who had received fluoxymesterone (100 mg/day). Elevation of serum FSH and LH to values equal to or greater than 100 milli-International Units (IRP-HMG) per ml was attained within approximately 20 days after surgical castration and 30–40 days after initiation of roentgen castration. The pattern of increase in FSH release following castration did not differ noticeably from the pattern of increase in LH release. Stilbestrol, in a daily dosage of either 0.1 or 0.2 mg, administered to 3 subjects, had either a slight effect or no effect on these elevated levels of serum FSH and LH post castration. In a dose of 1.0 mg, stilbestrol, administered to one subject, substanstantially reduced the elevated serum FSH and LH, but failed to return these values to precastration levels. This content is only available as a PDF. Author notes Supported by NIH Grant AM 11214, USPHS RCDA AM 7735, and Ford Foundation Grant 67–514. Copyright © 1970 by The Endocrine Society

Journal

Journal of Clinical Endocrinology and Metabolism – Oxford University Press

Published: Jul 1, 1970

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