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Granulomatous pyoderma gangrenosum: two unusual cases showing necrotizing granulomatous inflammation

Granulomatous pyoderma gangrenosum: two unusual cases showing necrotizing granulomatous inflammation We present two cases of pyoderma gangrenosum (PG) with unusual histopathological findings. The main histopathological feature of PG is usually massive neutrophilic infiltration; the neutrophil is thus the cytologic hallmark of PG. The occurrence of vasculitis is controversial. In our patients, in contrast, biopsy specimens revealed extensive granulomatous inflammation with massive tissue necrosis throughout the entire dermis and subcutaneous tissue and vascular involvement simulating many other granulomatous diseases. However, there was no evidence of systemic disease. Our cases may therefore represent a histopathologically distinct subset of PG. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Experimental Dermatology Oxford University Press

Granulomatous pyoderma gangrenosum: two unusual cases showing necrotizing granulomatous inflammation

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References (22)

Copyright
© 2000 British Association of Dermatologists
ISSN
0307-6938
eISSN
1365-2230
DOI
10.1046/j.1365-2230.2000.00721.x
Publisher site
See Article on Publisher Site

Abstract

We present two cases of pyoderma gangrenosum (PG) with unusual histopathological findings. The main histopathological feature of PG is usually massive neutrophilic infiltration; the neutrophil is thus the cytologic hallmark of PG. The occurrence of vasculitis is controversial. In our patients, in contrast, biopsy specimens revealed extensive granulomatous inflammation with massive tissue necrosis throughout the entire dermis and subcutaneous tissue and vascular involvement simulating many other granulomatous diseases. However, there was no evidence of systemic disease. Our cases may therefore represent a histopathologically distinct subset of PG.

Journal

Clinical and Experimental Dermatology – Oxford University Press

Published: Nov 1, 2000

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