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Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated α-subunit and β-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

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Publisher
Springer Journals
Copyright
Copyright © 1987 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/328221a0
Publisher site
See Article on Publisher Site

Abstract

Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated α-subunit and β-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.

Journal

Nature – Springer Journals

Published: Jul 16, 1987

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