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Chronic renal outcomes with proton pump inhibitors

Chronic renal outcomes with proton pump inhibitors Reactions 1642, p9 - 11 Mar 2017 Chronic renal outcomes with proton pump inhibitors Treatment with proton pump inhibitors is associated with an increased risk of chronic renal outcomes including chronic kidney disease (CKD) and end-stage renal disease (ESRD) even in the absence of intervening acute kidney injury (AKI), according to the results of a study reported in Kidney International, which suggests that "monitoring for AKI or acute interstitial nephritis . . . is not sufficient to guard against the development of CKD and ESRD". The study identified 118 793 new users of acid suppression therapy from US Department of Veterans Affairs national databases between 1 October 2006 and 30 September 2008. There were 125 596 proton pump inhibitor (PPI) recipients and 18 436 histamine H2 receptor blocker recipients. Patients were followed for 5 years; for the primary endpoint, patients were censored at the time of AKI occurrence. No AKI occurred at any time in 102 692 PPI recipients and 16 101 H2 blocker recipients. Patients receiving PPIs had an increased risk of renal adverse events, including eGFR <60 ml/min/1.73m (hazard ratio [HR] 1.19), eGFR decline >30% (HR 1.22), eGFR decline >50% or ESRD (HR 1.30) or incident chronic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Chronic renal outcomes with proton pump inhibitors

Reactions Weekly , Volume 1642 (1) – Mar 11, 2017
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Chronic renal outcomes with proton pump inhibitors

Abstract

Reactions 1642, p9 - 11 Mar 2017 Chronic renal outcomes with proton pump inhibitors Treatment with proton pump inhibitors is associated with an increased risk of chronic renal outcomes including chronic kidney disease (CKD) and end-stage renal disease (ESRD) even in the absence of intervening acute kidney injury (AKI), according to the results of a study reported in Kidney International, which suggests that "monitoring for AKI or acute interstitial nephritis . . . is not sufficient to...
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing Switzerland
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-017-27186-y
Publisher site
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Abstract

Reactions 1642, p9 - 11 Mar 2017 Chronic renal outcomes with proton pump inhibitors Treatment with proton pump inhibitors is associated with an increased risk of chronic renal outcomes including chronic kidney disease (CKD) and end-stage renal disease (ESRD) even in the absence of intervening acute kidney injury (AKI), according to the results of a study reported in Kidney International, which suggests that "monitoring for AKI or acute interstitial nephritis . . . is not sufficient to guard against the development of CKD and ESRD". The study identified 118 793 new users of acid suppression therapy from US Department of Veterans Affairs national databases between 1 October 2006 and 30 September 2008. There were 125 596 proton pump inhibitor (PPI) recipients and 18 436 histamine H2 receptor blocker recipients. Patients were followed for 5 years; for the primary endpoint, patients were censored at the time of AKI occurrence. No AKI occurred at any time in 102 692 PPI recipients and 16 101 H2 blocker recipients. Patients receiving PPIs had an increased risk of renal adverse events, including eGFR <60 ml/min/1.73m (hazard ratio [HR] 1.19), eGFR decline >30% (HR 1.22), eGFR decline >50% or ESRD (HR 1.30) or incident chronic

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Reactions Weekly – Springer Journals

Published: Mar 11, 2017

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