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Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune modulators

Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune... The regulation of the expression of indoleamine 2,3-dioxygenase (IDO) was studied in cloned murine macrophages (MT2) and microglial (N11) cells. Both cell lines express IDO and inducible nitric oxide synthase activity after interferon-γ (IFN-γ) stimulation. The regulation of IDO expression appears to differ in the two cell lines. Nitric oxide (NO) production negatively modulates the expression of IDO activity in IFN-γ-primed macrophages, thereby indicating a cross-talk between the kynurenine and nitridergic pathways in these cells. Conversely, this down-regulation of IDO activity by NO does not occour in microglial cells. A differential regulation of IDO expression in the two cell lines was also observed with LPS and picolinic acid. Together with previous findings, these results indicate the existence of marked differences in the regulation of the expression of the kynurenine pathway enzymes between macrophages and microglial cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Amino Acids Springer Journals

Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune modulators

Alberati-Giani, D.; Cesura, A.
Amino Acids , Volume 14 (3) – Mar 3, 2005
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References (18)

Publisher
Springer Journals
Copyright
Copyright © 1998 by Springer-Verlag
Subject
Life Sciences; Analytical Chemistry; Biochemical Engineering; Life Sciences, general; Biochemistry, general; Proteomics; Neurobiology
ISSN
0939-4451
eISSN
1438-2199
DOI
10.1007/BF01345271
Publisher site
See Article on Publisher Site

Abstract

The regulation of the expression of indoleamine 2,3-dioxygenase (IDO) was studied in cloned murine macrophages (MT2) and microglial (N11) cells. Both cell lines express IDO and inducible nitric oxide synthase activity after interferon-γ (IFN-γ) stimulation. The regulation of IDO expression appears to differ in the two cell lines. Nitric oxide (NO) production negatively modulates the expression of IDO activity in IFN-γ-primed macrophages, thereby indicating a cross-talk between the kynurenine and nitridergic pathways in these cells. Conversely, this down-regulation of IDO activity by NO does not occour in microglial cells. A differential regulation of IDO expression in the two cell lines was also observed with LPS and picolinic acid. Together with previous findings, these results indicate the existence of marked differences in the regulation of the expression of the kynurenine pathway enzymes between macrophages and microglial cells.

Journal

Amino Acids – Springer Journals

Published: Mar 3, 2005

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