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Comparison of stress–strain response of iPS cell-derived cardiomyocytes sheet and tube structures

Comparison of stress–strain response of iPS cell-derived cardiomyocytes sheet and tube structures Recently, human iPS cells derived cardiomyocytes (hiPS-CM) have been utilized as the power source of biological actuators. However, the detailed mechanical properties of hiPS-CM have not been well understood yet. The primary aim of this study was to characterize and compare the stress–strain responses of two-dimensional hiPS-CM sheet and three-dimensional tube structure under self-contractive deformation. Firstly, their pulsation behaviors were examined as the time variation of brightness using a high-speed imaging system. Then, the minimum principal strain values on the surfaces of the sheet and tube were measured using the digital correlation method with the consecutive digital images. The theoretical strain was fund to coincide with the experimental strain vey well, indicating the validity of the developed theoretical models. The stress–strain responses of the sheet and tube were then constructed using the active stress model and the experimental strain. It was found that both the stress–strain responses clearly exhibited viscoelastic behaviors characterized by the hysteresis loop. It was thus concluded that the mechanical responses of hiPS-CM structures could be characterized using the viscoelastic theory along with the active stress model. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mechanics of Soft Materials Springer Journals

Comparison of stress–strain response of iPS cell-derived cardiomyocytes sheet and tube structures

Todo, Mitsugu; Kurita, Hiroko
Mechanics of Soft Materials , Volume 4 (1) – Dec 1, 2022
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References (17)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
2524-5600
eISSN
2524-5619
DOI
10.1007/s42558-022-00048-z
Publisher site
See Article on Publisher Site

Abstract

Recently, human iPS cells derived cardiomyocytes (hiPS-CM) have been utilized as the power source of biological actuators. However, the detailed mechanical properties of hiPS-CM have not been well understood yet. The primary aim of this study was to characterize and compare the stress–strain responses of two-dimensional hiPS-CM sheet and three-dimensional tube structure under self-contractive deformation. Firstly, their pulsation behaviors were examined as the time variation of brightness using a high-speed imaging system. Then, the minimum principal strain values on the surfaces of the sheet and tube were measured using the digital correlation method with the consecutive digital images. The theoretical strain was fund to coincide with the experimental strain vey well, indicating the validity of the developed theoretical models. The stress–strain responses of the sheet and tube were then constructed using the active stress model and the experimental strain. It was found that both the stress–strain responses clearly exhibited viscoelastic behaviors characterized by the hysteresis loop. It was thus concluded that the mechanical responses of hiPS-CM structures could be characterized using the viscoelastic theory along with the active stress model.

Journal

Mechanics of Soft Materials – Springer Journals

Published: Dec 1, 2022

Keywords: iPS cell; Cardiomyocytes; Pulsation; Viscoelastic response; Hysteresis loop; Active stress

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