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Extensive elongation of axons from rat brain into peripheral nerve grafts

Extensive elongation of axons from rat brain into peripheral nerve grafts The failure of axons to elongate in the injured central nervous system (CNS) of adult mammals restricts drastically the establishment of connections with target tissues situated more than a few millimetres away. Mechanisms that include a primary inability of some nerve cells to support renewed axonal growth, a premature formation of synapses on nearby neurones1, an obstruction caused by the formation of a glial scar2,3 and other influences of the microenvironment4–7 are presumed to contribute to the failure of nerve fibres to regenerate as effectively in the CNS as in the peripheral nervous system (PNS). Support for the hypothesis that conditions in the glial environment of injured fibres have a decisive role in successful axonal elongation has recently come from studies using transplants containing either central glia or peripheral nerve segments as conduits of axon growth7,8. While CNS glial grafts have been shown to prevent growth of PNS fibres7–9, experiments which used labelling techniques to trace the source of axons growing into PNS grafts provided evidence that processes from nerve cells in the spinal cord and medulla oblongata of adult rats may increase in length by 1 or more centimetres when the CNS glial environment is replaced by that of peripheral nerves10,11. Here we report for the first time the extensive elongation of axons from neurones in the brain of adult rats through PNS grafts introduced into the cerebral hemispheres. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Extensive elongation of axons from rat brain into peripheral nerve grafts

Benfey, Martin; Aguayo, Albert J.
Nature , Volume 296 (5853) – Mar 11, 1982
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References (18)

Publisher
Springer Journals
Copyright
Copyright © 1982 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/296150a0
Publisher site
See Article on Publisher Site

Abstract

The failure of axons to elongate in the injured central nervous system (CNS) of adult mammals restricts drastically the establishment of connections with target tissues situated more than a few millimetres away. Mechanisms that include a primary inability of some nerve cells to support renewed axonal growth, a premature formation of synapses on nearby neurones1, an obstruction caused by the formation of a glial scar2,3 and other influences of the microenvironment4–7 are presumed to contribute to the failure of nerve fibres to regenerate as effectively in the CNS as in the peripheral nervous system (PNS). Support for the hypothesis that conditions in the glial environment of injured fibres have a decisive role in successful axonal elongation has recently come from studies using transplants containing either central glia or peripheral nerve segments as conduits of axon growth7,8. While CNS glial grafts have been shown to prevent growth of PNS fibres7–9, experiments which used labelling techniques to trace the source of axons growing into PNS grafts provided evidence that processes from nerve cells in the spinal cord and medulla oblongata of adult rats may increase in length by 1 or more centimetres when the CNS glial environment is replaced by that of peripheral nerves10,11. Here we report for the first time the extensive elongation of axons from neurones in the brain of adult rats through PNS grafts introduced into the cerebral hemispheres.

Journal

Nature – Springer Journals

Published: Mar 11, 1982

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