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- Publisher
- Wiley
- Copyright
- "© 2013 International Society for Neurochemistry"
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- DOI
- 10.1111/jnc.12334
- pmid
- 23745722
- Publisher site
- See Article on Publisher Site
Abstract
Aging and the presence of cerebrovascular disease are associated with increased incidence of Alzheimer's disease. A common feature of aging and cerebrovascular disease is decreased endothelial nitric oxide (NO). We studied the effect of a loss of endothelium derived NO on amyloid precursor protein (APP) related phenotype in late middle aged (LMA) (14–15 month) endothelial nitric oxide synthase deficient (eNOS−/−) mice. APP, β‐site APP cleaving enzyme (BACE) 1, and amyloid beta (Aβ) levels were significantly higher in the brains of LMA eNOS−/− mice as compared with LMA wild‐type controls. APP and Aβ1‐40 were increased in hippocampal tissue of eNOS−/− mice as compared with wild‐type mice. LMA eNOS−/− mice displayed an increased inflammatory phenotype as compared with LMA wild‐type mice. Importantly, LMA eNOS−/− mice performed worse in a radial arm maze test of spatial learning and memory as compared with LMA wild‐type mice. These data suggest that chronic loss of endothelial NO may be an important contributor to both Aβ related pathology and cognitive decline.
Journal
Journal of Neurochemistry – Wiley
Published: Dec 1, 2013
Keywords: ; ; ; ; ;