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Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in... Downloaded from genesdev.cshlp.org on November 7, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION Genome-wide analysis of Mammalian genomes are chemically modified by DNA 5-hydroxymethylcytosine cytosine methylation, an inheritable epigenetic mark that is implicated in many biological and pathological distribution reveals its dual processes, including gene regulation, genomic imprint- ing, X-chromosome inactivation, suppression of trans- function in transcriptional posable elements, and tumorigenesis (Cedar and Bergman regulation in mouse embryonic 2009; Ooi et al. 2009). Genome-wide studies of mamma- lian DNA methylation have shown that 5-methylcytosine stem cells (5mC) is widely distributed across the genome in a non- 1,2,7 3,4 3,4 random manner (Weber et al. 2007; Fouse et al. 2008; Hao Wu, Ana C. D’Alessio, Shinsuke Ito, Meissner et al. 2008; Lister et al. 2009). In conjunction 5 6 6 Zhibin Wang, Kairong Cui, Keji Zhao, with other epigenetic modifications, 5mC can regulate 1,2 3,4,8 Yi Eve Sun, and Yi Zhang accessibility of the DNA to transcription factors and chromatin regulators, thereby contributing to gene regu- Department of Molecular and Medical Pharmacology, lation and cellular differentiation. David Geffen School of Medicine, University of California at Recent studies have uncovered 5-hydroxymethylcyto- Los Angeles, Los Angeles, California 90095, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.2036011
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Abstract

Downloaded from genesdev.cshlp.org on November 7, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION Genome-wide analysis of Mammalian genomes are chemically modified by DNA 5-hydroxymethylcytosine cytosine methylation, an inheritable epigenetic mark that is implicated in many biological and pathological distribution reveals its dual processes, including gene regulation, genomic imprint- ing, X-chromosome inactivation, suppression of trans- function in transcriptional posable elements, and tumorigenesis (Cedar and Bergman regulation in mouse embryonic 2009; Ooi et al. 2009). Genome-wide studies of mamma- lian DNA methylation have shown that 5-methylcytosine stem cells (5mC) is widely distributed across the genome in a non- 1,2,7 3,4 3,4 random manner (Weber et al. 2007; Fouse et al. 2008; Hao Wu, Ana C. D’Alessio, Shinsuke Ito, Meissner et al. 2008; Lister et al. 2009). In conjunction 5 6 6 Zhibin Wang, Kairong Cui, Keji Zhao, with other epigenetic modifications, 5mC can regulate 1,2 3,4,8 Yi Eve Sun, and Yi Zhang accessibility of the DNA to transcription factors and chromatin regulators, thereby contributing to gene regu- Department of Molecular and Medical Pharmacology, lation and cellular differentiation. David Geffen School of Medicine, University of California at Recent studies have uncovered 5-hydroxymethylcyto- Los Angeles, Los Angeles, California 90095,

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Genes & Development – Unpaywall

Published: Apr 1, 2011

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