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UNAWARENESS OF MEMORY DEFICITS DEPENDING ON CEREBRAL PERFUSION PATTERN IN MILD COGNITIVE IMPAIRMENT

UNAWARENESS OF MEMORY DEFICITS DEPENDING ON CEREBRAL PERFUSION PATTERN IN MILD COGNITIVE IMPAIRMENT To the Editor: Although patients with Alzheimer's disease (AD) are often unaware of their cognitive or functional impairment, few studies have examined whether patients with mild cognitive impairment (MCI) are aware of their impairment. MCI is considered to refer to a transitional zone between normal cognitive function and dementia. It may represent a complex heterogenous condition. When subjects with MCI are followed over time, some progress to dementia, especially AD, but some are stable or even recover. Indeed, neuroimaging studies have showed that patients with MCI had a variety of cerebral perfusion patterns, from normal perfusion to a similar hypoperfusion pattern of AD. The correlation between the level of awareness of memory deficits and cerebral perfusion pattern in patients with MCI was investigated. Forty‐three consecutive outpatients with amnestic MCI, defined using an operationalization of criteria previously published were enrolled. Patients with a known or suspected cause of memory impairment (e.g., depression, anxiety disorder, alcohol abuse) were not classified as having MCI so as to include only patients with amnestic MCI. All patients underwent single photon emission computed tomography (SPECT) studies with 222MBq of N‐isopropyl‐p‐( 123 I) iodoamphetamine. SPECT data were analyzed using three‐dimensional stereotactic surface projections, and z‐score http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of American Geriatrics Society Wiley

UNAWARENESS OF MEMORY DEFICITS DEPENDING ON CEREBRAL PERFUSION PATTERN IN MILD COGNITIVE IMPAIRMENT

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References (22)

Publisher
Wiley
Copyright
© 2007,Copyright © 2007, The American Geriatrics Society
ISSN
0002-8614
eISSN
1532-5415
DOI
10.1111/j.1532-5415.2007.01074.x
pmid
17341256
Publisher site
See Article on Publisher Site

Abstract

To the Editor: Although patients with Alzheimer's disease (AD) are often unaware of their cognitive or functional impairment, few studies have examined whether patients with mild cognitive impairment (MCI) are aware of their impairment. MCI is considered to refer to a transitional zone between normal cognitive function and dementia. It may represent a complex heterogenous condition. When subjects with MCI are followed over time, some progress to dementia, especially AD, but some are stable or even recover. Indeed, neuroimaging studies have showed that patients with MCI had a variety of cerebral perfusion patterns, from normal perfusion to a similar hypoperfusion pattern of AD. The correlation between the level of awareness of memory deficits and cerebral perfusion pattern in patients with MCI was investigated. Forty‐three consecutive outpatients with amnestic MCI, defined using an operationalization of criteria previously published were enrolled. Patients with a known or suspected cause of memory impairment (e.g., depression, anxiety disorder, alcohol abuse) were not classified as having MCI so as to include only patients with amnestic MCI. All patients underwent single photon emission computed tomography (SPECT) studies with 222MBq of N‐isopropyl‐p‐( 123 I) iodoamphetamine. SPECT data were analyzed using three‐dimensional stereotactic surface projections, and z‐score

Journal

Journal of American Geriatrics Society – Wiley

Published: Mar 1, 2007

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