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The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork... Downloaded from genesdev.cshlp.org on December 15, 2021 - Published by Cold Spring Harbor Laboratory Press The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart 1,4 1,4 2 3 Alberto Ciccia, Andrea L. Bredemeyer, Mathew E. Sowa, Marie-Emilie Terret, 3 2 1,5 Prasad V. Jallepalli, J. Wade Harper, and Stephen J. Elledge Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA; Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA The integrity of genomic DNA is continuously challenged by the presence of DNA base lesions or DNA strand breaks. Here we report the identification of a new DNA damage response protein, SMARCAL1 (SWI/SNF-related, matrix associated, actin-dependent regulator of chromatin, subfamily a-like 1), which is a member of the SNF2 family and is mutated in Schimke immunoosseous dysplasia (SIOD). We demonstrate that SMARCAL1 directly interacts with Replication protein A (RPA) and is recruited to sites of DNA damage in an RPA-dependent manner. SMARCAL1-depleted cells display sensitivity to DNA-damaging agents that induce replication fork collapse, and exhibit slower fork recovery http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1832309
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Abstract

Downloaded from genesdev.cshlp.org on December 15, 2021 - Published by Cold Spring Harbor Laboratory Press The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart 1,4 1,4 2 3 Alberto Ciccia, Andrea L. Bredemeyer, Mathew E. Sowa, Marie-Emilie Terret, 3 2 1,5 Prasad V. Jallepalli, J. Wade Harper, and Stephen J. Elledge Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA; Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA The integrity of genomic DNA is continuously challenged by the presence of DNA base lesions or DNA strand breaks. Here we report the identification of a new DNA damage response protein, SMARCAL1 (SWI/SNF-related, matrix associated, actin-dependent regulator of chromatin, subfamily a-like 1), which is a member of the SNF2 family and is mutated in Schimke immunoosseous dysplasia (SIOD). We demonstrate that SMARCAL1 directly interacts with Replication protein A (RPA) and is recruited to sites of DNA damage in an RPA-dependent manner. SMARCAL1-depleted cells display sensitivity to DNA-damaging agents that induce replication fork collapse, and exhibit slower fork recovery

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Genes & Development – Unpaywall

Published: Sep 30, 2009

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