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- Publisher
- Springer Journals
- Copyright
- Copyright
- Subject
- Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
- ISSN
- 0312-5963
- eISSN
- 1179-1926
- DOI
- 10.2165/00003088-197803040-00001
- Publisher site
- See Article on Publisher Site
Abstract
A number of examples of altered drug disposition in patients with respiratory disease have been reported. These reports have been analysed in terms of absorption, distribution and elimination. The changes have been examined mechanistically in light of the pathophysiology of respiratory disease and the known influence of these physiological parameters on drug disposition. Our analysis has included in vivo and in vitro data from laboratory animals in addition to appropriate data from humans.
Journal
Clinical Pharmacokinetics – Springer Journals
Published: Dec 15, 2012