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- Publisher
- Taylor & Francis
- Copyright
- Copyright Taylor & Francis Group, LLC
- ISSN
- 1532-2327
- eISSN
- 0732-8303
- DOI
- 10.1080/07328300802262778
- Publisher site
- See Article on Publisher Site
Abstract
N‐Arylaminomethyl‐3H‐1,3,4‐oxadiazole‐2‐thiones 2a,b were prepared from the corresponding N‐arylglycinoylhydrazides. A number of their thioglycoside derivatives 4–7a–c and S‐functionalized analogs 8–11a,b were synthesized by the reaction with different acetobromosugars and acyclic hydroxyalkylating agents. The antiviral activity of a number of the synthesized compounds against herpes simplex virus type 1 (HSV‐1) and hepatitis A virus (HAV) was evaluated. Compounds 5a and 5b showed promising results against HAV.
Journal
Journal of Carbohydrate Chemistry – Taylor & Francis
Published: Aug 1, 2008
Keywords: Thioglycosides; Oxadiazole; S ‐Functionalized‐oxadiazole; Glycinoyl hydrazine; Antiviral activity; Herpes simplex virus type 1 (HSV‐1); Hepatitis A virus (HAV)