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(2002)
Signal transduction pathway activated by toll-like receptors
- Publisher
- Oxford University Press
- Copyright
- © 2005 British Association of Dermatologists
- ISSN
- 0007-0963
- eISSN
- 1365-2133
- DOI
- 10.1111/j.1365-2133.2005.06933.x
- Publisher site
- See Article on Publisher Site
Abstract
SummaryBackground The bacterium Propionibacterium acnes is involved in the induction and maintenance of the inflammatory phase of acne. Recent studies have found that keratinocytes express toll‐like receptors (TLRs) implicated in immediate immunity. No studies have, to date, been carried out on the action of P. acnes upon TLR activation in keratinocytes.Objectives Focusing on the inflammatory phase of acne, to clarify the role of P. acnes in immediate immunity by inducing expression of TLR‐2 and TLR‐4 by keratinocytes. We also studied how the secretion and expression of matrix metalloproteinase (MMP)‐9 is induced by P. acnes.Methods The work was carried out on two levels: in vivo with the study of the expression of TLR‐2 and TLR‐4 proteins in biopsies of acne lesions and in vitro on cultured keratinocyte monolayers to study the modulating effects of P. acnes on the expression of TLR‐2 and TLR‐4 and also on the expression and secretion of MMP‐9.Results Our findings reveal that in vivo TLR‐2 and TLR‐4 expression is increased in the epidermis of acne lesions. In vitro, an increase in TLR‐2 and TLR‐4 expression by human keratinocytes occurred in the first hours of incubation with bacterial fractions as well as an increase of the expression and secretion by the keratinocytes of MMP‐9, which plays a role in inflammation.Conclusions This work demonstrates that P. acnes induces TLR expression and that this mechanism could play an essential role in acne‐linked inflammation. These receptors could be involved notably in acute acne.
Journal
British Journal of Dermatology – Oxford University Press
Published: Dec 1, 2005
Keywords: acne; epidermis; inflammation; innate immunity; matrix metalloproteinase‐9; toll‐like receptors