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- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Springer-Verlag
- Subject
- Medicine & Public Health; Hematology; Internal Medicine ; Cancer Research ; Oncology
- ISSN
- 0171-5216
- eISSN
- 1432-1335
- DOI
- 10.1007/s00432-008-0538-4
- pmid
- 19125294
- Publisher site
- See Article on Publisher Site
Abstract
J Cancer Res Clin Oncol (2009) 135:1025–1031 DOI 10.1007/s00432-008-0538-4 ORIGINAL PAPER Down-regulation of ribosomal protein L7A in human osteosarcoma Shui-er Zheng · Yang Yao · Yang Dong · Feng Lin · Hui Zhao · Zan Shen · Yuan-jue Sun · Li-na Tang Received: 31 August 2008 / Accepted: 15 December 2008 / Published online: 6 January 2009 © Springer-Verlag 2008 Abatract tumor location, histological type, histological grading, lung Purpose To explore the expression of ribosomal protein metastasis and overall survival. Interestingly, survival anal- L7A (RPL7A) in osteosarcoma and its correlation with ysis suggested low RPL7A mRNA expression was a sig- clinical features. niWcant poor prognostic indicator for overall survival in Methods Ribosomal protein L7A mRNA expression was patients with high grade lesion developed lung metastasis at quantiWed by real-time reverse transcription (RT)-polymer- the time of diagnosis of the primary osteosarcoma ase chain reaction (PCR) in 47 specimens from osteosar- (P < 0.05). On western blot, reduced expression of RPL7A coma, 8 from normal bone tissues and 12 from benign bone protein was observed in osteosarcoma samples (n = 20) lesion tissues. Expression of RPL7A mRNA was also compared with normal bone (n =8) (P < 0.001) and benign detected
Journal
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Jan 6, 2009